Table 1 The list of the most promising candidate genes identified in the Pairl1 locus

Dok1

Adaptor protein involved in:

• lung homeostasis

• negative regulation of LPS signaling

• Downregulation of its expression in in vitro models

[28, 29]

Tacr1

Receptor for neuropeptide tachykinin involved in:

• Cytokines and chemokines expression

• Chemotaxis and neutrophils activation

• P. aeruginosa corneal infection

[30–32]

Cd207

Clecf4

Members of C-type lectin superfamily involved in:

• Pathogen sensing of virus, fungi and bacteria

[33–35]

Gp9

Glycoprotein 9-Glycoprotein Ib complex involved in:

• Leukocytes migration

• Inflammation

• Neutrophils extracellular trap formation

[36]

Foxp1

Gata2

Transcriptional factors involved in:

• Cytokines expression

[37, 38]