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Table 4 Genes involved in the TH axis identified in the Atlantic halibut head, skin and GI-tract transcriptomes

From: The transcriptome of metamorphosing flatfish

Protein name Acronym Accession no. Organism Head Skin GI-tract Biological role
Thyrotropin-releasing hormone TRH ACI68323 Salmo salar lchead_c49703    Hormone-mediated signalling pathway
Bteb1 protein Klf9 Q8CEC4 Mus musculus lchead_c5876 lcst_c61990   Cellular response to thyroid hormone stimulus
Cathepsin B Ctsb P10605 Mus musculus lchead_rep_c17340   lcgut_c971
Cathepsin S Ctss Q3UD32 Mus musculus lchead_c2408 lcst_c25054  
GAS2-like protein 1 Gas2l1 Q8JZP9 Mus musculus lchead_c63583   
Mediator of RNA polymerase II transcription subunit 1 Med1 Q925J9 Mus musculus lchead_c54375 lcst_c53801  
Rhombotin-2 Lmo2 A2BHP2 Mus musculus lchead_rep_c19211   
Tyrosine-protein kinase receptor Kit Q63116 Rattus norvegicus lchead_c88982   lcgut_c981
GATA binding protein 3 GATA 3 Q0ZHH4 Sus scrofa lchead_c10759    Positive regulation of thyroid hormone generation
Serine protease hepsin Hpn O35453 Mus musculus lchead_c1056 lcst_c55583  
Fibroblast growth factor 10 Fgf10 O35565 Mus musculus lchead_c59444    Thyroid gland development
Forkhead box E3 foxe3 B0UXI3 Danio rerio lchead_c14669 lcst_c7916  
Heart and neural crest derivatives expressed transcript 2 hand2 Q5XJD8 Danio rerio lchead_c14402   
Hematopoietically-expressed homeobox protein hhex hhex Q9IAV3 Danio rerio lchead_c76036   
Homeobox protein Nkx2.1a nkx2.1a Q9I8L7 Danio rerio lchead_rep_c28603   
MAD homolog 3 Smad3 A2CG44 Mus musculus lchead_c8437 lcst_c2973 lcgut_c21904
NK2 homeobox 1 Nkx2-1 Q6PFE0 Mus musculus lchead_rep_c45357   
Sonic hedgehog protein Shh Q62226 Mus musculus lchead_c10675   lcgut_c2545
T-cell acute lymphocytic leukemia protein 1 homolog tal1 O93507 Danio rerio lchead_c1186   
Thyroglobulin Tg O08710 Mus musculus lchead_c4966   
Transcription factor gata5 gata5 Q9W6U0 Danio rerio lchead_c49264   
Transforming growth factor beta-2 Tgfb2 P27090 Mus musculus lchead_rep_c18013 lcst_c97  
Vascular endothelial growth factor A-A vegfaa O73682 Danio rerio lchead_rep_c38578   
Vascular endothelial growth factor receptor kdr-like kdrl Q8AXB3 Danio rerio lchead_c15716   
Aldehyde dehydrogenase family 1 member A3 Aldh1a3 G3UWP3 Mus musculus lchead_rep_c51532    Thyroid hormone binding
Cathepsin H CTSH B2D1T2 Sus scrofa lchead_rep_c18375 lcst_c35788  
Retinaldehyde dehydrogenase 3 ALDH6 Q9DD46 Gallus gallus lchead_c4855 lcst_c276  
Estrogen receptor alpha - Q2PUG8 Hippoglossus hippoglossus lchead_c11863    Thyroid hormone receptor activity
Farnesoid X activated receptor - Q8SPF5 Oryctolagus cuniculus lchead_c38827   
Nuclear receptor subfamily 1, group D, member 4 nr1d4a B8A510 Danio rerio lchead_c5000 lcst_c4716  
Nuclear receptor subfamily 1, group D, member 1 nr1d1 Q503Y6 Danio rerio lchead_c56865   lcgut_c766
Nuclear receptor subfamily 2, group E, member 3 nr2e3 A0FCT3 Xenopus tropicalis lchead_rep_c19272 lcst_c50411  
Nuclear receptor subfamily 1, group H, member 4 nr1h4 Q6DGW7 Danio rerio lchead_c38092   
Orphan nuclear receptor BXR-beta nr1i2 Q9DF24 Xenopus laevis lchead_c53830   
Orphan nuclear receptor HZF-2 Nr1d2 Q62702 Rattus norvegicus lchead_c13737   
Rev-erbgamma-B nr1d4b Q1L683 Danio rerio lchead_c801   
Thyroid hormone receptor alpha B TRαB B7XBZ0 Solea senegalensis lchead_c73126 lcst_c51070  
Thyroid hormone receptor beta TRβ A8R655 Solea senegalensis lchead_c15487 lcst_c29077  
Monocarboxylate transporter 10 MCT10 NP_001073497 Danio rerio lchead_c4262 lcst_c309   Thyroid hormone transmembrane transporter activity
Solute carrier organic anion transporter family member 1A5 Slco1a5 E0CX25 Mus musculus lchead_c60364   
Solute carrier organic anion transporter family member 4A1 Slco4a1 Q8K078 Mus musculus lchead_c13235   
Thyroxine-binding globulin Serpina7 P35577 Rattus norvegicus lchead_c2058   
Monocarboxylate transporter 8 MCT8 NP_001245159 Danio rerio lchead_c13478 lcst_c54175 lcgut_c2689
Canalicular multispecific organic anion transporter 1 Abcc2 Q63120 Rattus norvegicus lchead_c7363   lcgut_c1215
Paired box protein Pax-8 PAX8 Q06710 Homo sapiens lchead_c53444    Thyroid-stimulating hormone receptor activity
Thyroid stimulating hormone receptor tshr F1Q981 Danio rerio lchead_c79782   
Iodothyronine deiodinase type I DIO1 B1B569 Takifugu rubripes lchead_c4984 lcst_c3609 lcgut_c27346 Thyroxine 5-deiodinase activity
Iodothyronine deiodinase type II DIO2 B3Y056 Oryzias latipes lchead_c13614   
Iodothyronine deiodinase type III DIO3 B1B572 Takifugu rubripes lchead_c39730 lcst_c58807  
  1. List of candidate genes identified in the Atlantic halibut head transcriptome with a role in thyroid gland development and thyroid hormone (TH) synthesis, transport and activity. Protein name, symbol, accession number (no.) and organism are shown for each gene product and they are grouped by biological function (when associated). Contig ID from the head, GI-tract and skin transcriptome assembly is given