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Table 4 Genes involved in the TH axis identified in the Atlantic halibut head, skin and GI-tract transcriptomes

From: The transcriptome of metamorphosing flatfish

Protein name

Acronym

Accession no.

Organism

Head

Skin

GI-tract

Biological role

Thyrotropin-releasing hormone

TRH

ACI68323

Salmo salar

lchead_c49703

  

Hormone-mediated signalling pathway

Bteb1 protein

Klf9

Q8CEC4

Mus musculus

lchead_c5876

lcst_c61990

 

Cellular response to thyroid hormone stimulus

Cathepsin B

Ctsb

P10605

Mus musculus

lchead_rep_c17340

 

lcgut_c971

Cathepsin S

Ctss

Q3UD32

Mus musculus

lchead_c2408

lcst_c25054

 

GAS2-like protein 1

Gas2l1

Q8JZP9

Mus musculus

lchead_c63583

  

Mediator of RNA polymerase II transcription subunit 1

Med1

Q925J9

Mus musculus

lchead_c54375

lcst_c53801

 

Rhombotin-2

Lmo2

A2BHP2

Mus musculus

lchead_rep_c19211

  

Tyrosine-protein kinase receptor

Kit

Q63116

Rattus norvegicus

lchead_c88982

 

lcgut_c981

GATA binding protein 3

GATA 3

Q0ZHH4

Sus scrofa

lchead_c10759

  

Positive regulation of thyroid hormone generation

Serine protease hepsin

Hpn

O35453

Mus musculus

lchead_c1056

lcst_c55583

 

Fibroblast growth factor 10

Fgf10

O35565

Mus musculus

lchead_c59444

  

Thyroid gland development

Forkhead box E3

foxe3

B0UXI3

Danio rerio

lchead_c14669

lcst_c7916

 

Heart and neural crest derivatives expressed transcript 2

hand2

Q5XJD8

Danio rerio

lchead_c14402

  

Hematopoietically-expressed homeobox protein hhex

hhex

Q9IAV3

Danio rerio

lchead_c76036

  

Homeobox protein Nkx2.1a

nkx2.1a

Q9I8L7

Danio rerio

lchead_rep_c28603

  

MAD homolog 3

Smad3

A2CG44

Mus musculus

lchead_c8437

lcst_c2973

lcgut_c21904

NK2 homeobox 1

Nkx2-1

Q6PFE0

Mus musculus

lchead_rep_c45357

  

Sonic hedgehog protein

Shh

Q62226

Mus musculus

lchead_c10675

 

lcgut_c2545

T-cell acute lymphocytic leukemia protein 1 homolog

tal1

O93507

Danio rerio

lchead_c1186

  

Thyroglobulin

Tg

O08710

Mus musculus

lchead_c4966

  

Transcription factor gata5

gata5

Q9W6U0

Danio rerio

lchead_c49264

  

Transforming growth factor beta-2

Tgfb2

P27090

Mus musculus

lchead_rep_c18013

lcst_c97

 

Vascular endothelial growth factor A-A

vegfaa

O73682

Danio rerio

lchead_rep_c38578

  

Vascular endothelial growth factor receptor kdr-like

kdrl

Q8AXB3

Danio rerio

lchead_c15716

  

Aldehyde dehydrogenase family 1 member A3

Aldh1a3

G3UWP3

Mus musculus

lchead_rep_c51532

  

Thyroid hormone binding

Cathepsin H

CTSH

B2D1T2

Sus scrofa

lchead_rep_c18375

lcst_c35788

 

Retinaldehyde dehydrogenase 3

ALDH6

Q9DD46

Gallus gallus

lchead_c4855

lcst_c276

 

Estrogen receptor alpha

-

Q2PUG8

Hippoglossus hippoglossus

lchead_c11863

  

Thyroid hormone receptor activity

Farnesoid X activated receptor

-

Q8SPF5

Oryctolagus cuniculus

lchead_c38827

  

Nuclear receptor subfamily 1, group D, member 4

nr1d4a

B8A510

Danio rerio

lchead_c5000

lcst_c4716

 

Nuclear receptor subfamily 1, group D, member 1

nr1d1

Q503Y6

Danio rerio

lchead_c56865

 

lcgut_c766

Nuclear receptor subfamily 2, group E, member 3

nr2e3

A0FCT3

Xenopus tropicalis

lchead_rep_c19272

lcst_c50411

 

Nuclear receptor subfamily 1, group H, member 4

nr1h4

Q6DGW7

Danio rerio

lchead_c38092

  

Orphan nuclear receptor BXR-beta

nr1i2

Q9DF24

Xenopus laevis

lchead_c53830

  

Orphan nuclear receptor HZF-2

Nr1d2

Q62702

Rattus norvegicus

lchead_c13737

  

Rev-erbgamma-B

nr1d4b

Q1L683

Danio rerio

lchead_c801

  

Thyroid hormone receptor alpha B

TRαB

B7XBZ0

Solea senegalensis

lchead_c73126

lcst_c51070

 

Thyroid hormone receptor beta

TRβ

A8R655

Solea senegalensis

lchead_c15487

lcst_c29077

 

Monocarboxylate transporter 10

MCT10

NP_001073497

Danio rerio

lchead_c4262

lcst_c309

 

Thyroid hormone transmembrane transporter activity

Solute carrier organic anion transporter family member 1A5

Slco1a5

E0CX25

Mus musculus

lchead_c60364

  

Solute carrier organic anion transporter family member 4A1

Slco4a1

Q8K078

Mus musculus

lchead_c13235

  

Thyroxine-binding globulin

Serpina7

P35577

Rattus norvegicus

lchead_c2058

  

Monocarboxylate transporter 8

MCT8

NP_001245159

Danio rerio

lchead_c13478

lcst_c54175

lcgut_c2689

Canalicular multispecific organic anion transporter 1

Abcc2

Q63120

Rattus norvegicus

lchead_c7363

 

lcgut_c1215

Paired box protein Pax-8

PAX8

Q06710

Homo sapiens

lchead_c53444

  

Thyroid-stimulating hormone receptor activity

Thyroid stimulating hormone receptor

tshr

F1Q981

Danio rerio

lchead_c79782

  

Iodothyronine deiodinase type I

DIO1

B1B569

Takifugu rubripes

lchead_c4984

lcst_c3609

lcgut_c27346

Thyroxine 5-deiodinase activity

Iodothyronine deiodinase type II

DIO2

B3Y056

Oryzias latipes

lchead_c13614

  

Iodothyronine deiodinase type III

DIO3

B1B572

Takifugu rubripes

lchead_c39730

lcst_c58807

 
  1. List of candidate genes identified in the Atlantic halibut head transcriptome with a role in thyroid gland development and thyroid hormone (TH) synthesis, transport and activity. Protein name, symbol, accession number (no.) and organism are shown for each gene product and they are grouped by biological function (when associated). Contig ID from the head, GI-tract and skin transcriptome assembly is given