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Fig. 3 | BMC Genomics

Fig. 3

From: Seasonal immunoregulation in a naturally-occurring vertebrate

Fig. 3

ARACNe networks of seasonally-biased core immune genes. Winter- and summer-biased nodes segregate to different regions of networks and interface via a small set of central nodes that are highly connected amongst themselves and also within their respective winter- or summer-biased set. a Network 1. Nodes sized according to their betweenness-centrality (a measure of centrality and thus potential influence within a network); network shown with a force-directed layout, modified to highlight edges (dashed) between summer and winter-biased genes (entire network stretched laterally with winter and summer regions displaced from each other vertically). b Network 1 re-analyzed with summer-biased timeless added as an extra node; nodes sized according to eccentricity (an inverse centrality measure) and shown with an unmodified force-directed layout. Edges from timeless connect to winter-summer interface genes and further winter-biased genes

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