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Table 3 Gene ontology (GO) enrichment of statistically significant (FDR < 0.15) GO terms for the Ugandan ecotypes

From: Genomic analysis of Ugandan and Rwandan chicken ecotypes using a 600 k genotyping array

Population GO ID Gene ontology term Genes under GO term Related environmental stressor(s) Reference
Ugandan Ecotypes GO:0065008 Regulation of biological quality PDIA5, CADPS2, TNIP2, CNOT6L, DISP3, ABCA4, PRKCA, SIN3A, PEX11A, DLG1, MC4R, RC3H1, NPY, SMAD1, CNGA2, RCOR1, RAP1GDS1, NAT8L, BICD2, SYNE1, ATP9A, STX12 Growth response to Environmental Stress UniProt [67], Jenuth 2000 [69, 77]
  GO:0001816 Cytokine production DLG1, TRIB2, MAP3K7, EIF2AK2, SNAI2 Pathogen/Predator Welc et al. 2013 [56]
  GO:0043122 Regulation of I- kappaB kinase/NF-kappaB signaling TNIP2, ZFAND6, ZDHHC17, MAP3K7 Inflammation/Oxidative Stress Evans et al. 2002 [46], Perkins et al. 2007 [55] Salminen et al. 2008 [87], Tam et al. 2012 [88]
  GO:0016627 Oxidoreductase activity, acting on the CH-CH group of donors TECRL, DYPD Oxidative stress UniProt [67], Jenuth 2000 [69, 77], Lee et al. 2007 [89]
  GO:0005215 Phospholipid transporter activity ABCA4, ATP9A Lipid Metabolism, phospholipid transfer to membrane UniProt [67], Jenuth 2000 [69, 77]
  GO:0080134 Regulation of response to stress TNIP2, PSMB4, MAP3K7, SIN3A, MID1, EIF2AK2, SNAI2 Oxidative/Metabolic/Environmental Stress UniProt [67], Puvadolpirod et al. 2000 [48], Li et al. 2011 [70], Yen et al. 2014 [90]
  GO:1901224 Positive regulation of NIK/NF-kappaB signaling RC3H1, MAP3K7, EIF2AK2 Inflammation/Oxidative Stress Evans et al. 2002 [46], Perkins et al. 2007 [55], Salminen et al. 2008 [87], Tam et al. 2012 [88]
  GO:0031098 Stress-activated protein kinase signaling cascade MAP3K7, MID1, EIF2AK2 Oxidative/Environmental Stress Li et al. 2011 [70], Yen et al. 2014 [90]
  GO:0006915 Apoptotic process TNIP2, SUDS3, ROBO1, ZFAND6, DNAJC5, MAP3K7, LCMT1, SIN3A, GRK5, EIF2AK2, SHQ1, CHL1, COMP, LFABP, SNAI2 Oxidative/Environmental Stress Galvez et al. 2001 [47]
  GO:0032874 Positive regulation of stress-activated MAPK cascade MAP3K7, MID1, EIF2AK2 Oxidative/Environmental Stress UniProt [67], Jenuth 2000 [69, 77]
  GO:0006950 Response to stress PDIA5, CADPS2, TNIP2, PSMB4, MAP3K7, UBE2T, SIN3A, EIF2AK2, MMP7, CXCR4, MID1, PAX-7, LFABP, SMAD1, SNAI2 Oxidative/Environmental Stress UniProt [67], Puvadolpirod et al. 2000 [48], Li et al. 2011 [70], Yen et al. 2014 [90]
  GO:0009719 Response to endogenous stimulus MC4R, GRB10, DISP3, MAP3K7, SMAD1, STMN2, SNAI2 Oxidative/Environmental Stress Evans et al. 2002 [46]
  GO:0034976 Response to endoplasmic reticulum stress PDIA5, EIF2AK2 Oxidative/Environmental Stress Evans et al. 2002 [46], Zhang et al. 2008 [54]