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Table 4 Gene ontology (GO) enrichment of statistically significant (FDR < 0.15) GO terms for the Rwandan ecotypes

From: Genomic analysis of Ugandan and Rwandan chicken ecotypes using a 600 k genotyping array

Population GO ID Gene ontology term Genes under GO term Related environmental stressor(s) Reference
Rwandan Ecotypes GO:0004697 Protein kinase C activity PRKCA, PRKD1 Oxidative stress UniProt [67], Jenuth 2000 [69, 77]
  GO:0046649 Lymphocyte activation DLG1, GPAM, ZBTB16, PREX1, CD151 Pathogen/Predator Flint et al. 2011 [91]
  GO:0006954 Inflammatory response PSMB4, UACA Pathogen/Predator Evans et al. 2002 [46], Zhang et al. 2008 [54]
  GO:0006950 Response to stress SEL1L, PSMB4, SIRT6, NEK6, BCAS3, GPAM, LIG3, UACA, PRKD1, SNAI2, SMAD1 Growth response to Environmental Stress UniProt [67], Puvadolpirod et al. 2000 [48], Li et al. 2011 [70], Yen et al. 2014 [90]
  GO:0007249 I-kappaB kinase/NF-kappaB signaling UACA, ZDHHC17, NEK6, PRKD1 Inflammation/Oxidative Stress Evans et al. 2002 [46], Perkins et al. 2007 [55], Salminen et al. 2008 [87], Tam et al. 2012 [88]
  GO:0034599 Cellular response to oxidative stress UACA, PRKD1 Oxidative/Environmental Stress UniProt [67], Jenuth 2000 [69, 77]
  GO:0009719 Response to endogenous stimulus HPGD, GRB10, CITED3, GABRB3, BCAS3, SMAD1, STMN2, SNAI2 Oxidative/Metabolic stress Evans et al. 2002 [46]
  GO:0048010 Vascular endothelial growth factor receptor signaling pathway GRB10, PRKD1 Oxidative/Metabolic Stress Koch et al. 2012 [57]
  GO:0043281 Regulation of cysteine-type endopeptidase activity involved in apoptotic process DLC1, RFFL, UACA Metabolic stress Galvez et al. 2001 [47]
  GO:0065008 Regulation of biological quality DLC1, PRKCA, RAP1GDS1, DLG1, GPAM, FRMPD4, GRM8, CRTC1, NPY, PTPN3, STX12, SMAD1 Growth response to Environmental Stress UniProt [67], Jenuth 2000 [69, 77]
  GO:0006915 Apoptotic process ZBTB16, DLC1, RFFL, SUDS3, DNAJC5, SHQ1, GPAM, UACA, GABRB3, UTP11L, SNAI2 Metabolic stress Galvez et al. 2001 [47]