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Table 5 Gene ontology (GO) enrichment of statistically significant (FDR < 0.15) GO terms for the Kuroilers

From: Genomic analysis of Ugandan and Rwandan chicken ecotypes using a 600 k genotyping array

Population GO ID Gene ontology term Genes under GO term Related environmental stressor(s) Reference
Kuroilers GO:0060584 Regulation of prostaglandin-endoperoxide synthase activity EDN2, EDN1 Oxidative stress/Pathogen Lee et al. 2007 [89]
  GO:0007631 Feeding behavior HCRTR2, HTR1B, GRIN1, NPY1R, ASIP Nutrient stress UniProt [67], Jenuth 2000 [69, 77]
  GO:0032693 Negative regulation of interleukin-10 production TRIB2, IL-12B Pathogen UniProt [67], Jenuth 2000 [69, 77]
  GO:0051341 Regulation of oxidoreductase activity ACVR2A, EDN2, EDN1, SNCA Oxidative stress/Pathogen UniProt [67], Jenuth 2000 [69, 77], Lee et al. 2007 [89]
  GO:0007618 Mating ACVR2A, SERPINE2, GRIN1 Survival Behavior UniProt [67], Jenuth 2000 [69, 77]
  GO:0016627 Oxidoreductase activity, acting on the CH-CH group of donors IVD, CPOX, ACAD9, DHCR24 Oxidative/Environmental Stress UniProt [67], Jenuth 2000 [69, 77], Lee et al. 2007 [89]
  GO:0006950 Response to stress ENTPD1, ETFDH, WNT5A CHID1, RBBP5, NEDD4, NSMCE2, GLP1R, STX2, LEAP2, RAB23, DEAF1, TNFSF11, PPP2R5C, DRD4, ZC3HAV1, CDH8, PPAP2B, GTF2H5, MCPH1, EDN1, FAM175B, GCLM, JAK1, UBXN2A, MID1, BATF, CPEB2, IL12B, PIK3AP1, SOX2, SNCA, CITED2, CHAC1, DTL, HIPK3, NOS1, STT3B, PDIA4, SBNO2, NUAK1, CDC7, SERPINE2, ULK1, MASP2, WFS1, DHCR24, PRKD1 Oxidative/Metabolic/Environmental Stress UniProt [67], Puvadolpirod et al. 2000 [48], Li et al. 2011 [70], Yen et al. 2014 [90]
  GO:0080134 Regulation of response to stress WNT5A, CHID1, PIK3AP1, IL12B, STX2, SNCA, HIPK3, TNFSF11, ZC3HAV1, PPAP2B, SBNO2, NUAK1, MCPH1, EDN1, SERPINE2, ULK1, WFS1, MID1 Oxidative/Metabolic/Environmental Stress UniProt [67], Puvadolpirod et al. 2000 [48], Li et al., 2011, Yen et al., 2014
  GO:0033554 Cellular response to stress WNT5A, RBBP5, BATF, CPEB2, NEDD4, NSMCE2, SNCA, CHAC1, CITED2, DTL, HIPK3, RAB23, TNFSF11, PPP2R5C, PDIA4, GTF2H5, NUAK1, FAM175B, EDN1, CDC7, ULK1, WFS1, UBXN2A, MID1, PRKD1 Oxidative/Metabolic/Environmental Stress UniProt [67], Puvadolpirod et al. 2000 [48]
  GO:0045859 Regulation of protein kinase activity TNFSF11, DRD4, WNT5A, TGFBR2, RAPGEF2, PDGF, PIK3CA, KIAA1199, LATS2, IL12B, EDN1, PAQR3, SNCA, GTPBP4, HIPK3 Oxidative/Metabolic/Environmental Stress UniProt [67], Jenuth 2000 [69, 77]
  GO:0003100 Regulation of systemic arterial blood pressure by endothelin EDN2, EDN1 Oxidative/Metabolic Stress Endemann et al. 2004 [20], Gomez et al. 2007 [21]
  GO:0048010 Vascular endothelial growth factor receptor signaling pathway FIGF, NEDD4, GRB10, PRKD1 Oxidative/Metabolic Stress Koch et al., 2012 [57]
  GO:0004674 Protein serine/threonine kinase activity CDC42BPB, DCLK1, TGFBR3, TGFBR2, PRKCA, LATS2, ACVR2A, NUAK1, CDC7, ULK1, CDC2L1, HIPK3, VRK1, PRKD1 Oxidative/Metabolic/Environmental Stress UniProt [67], Evans et al. 2002 [46], Perkins et al. 2007 [55], Salminen et al. 2008 [87], Tam et al., 2012 [88]
  GO:0009628 Response to abiotic stimulus GPR65, GRIN1, CASP8, IL12B, CPEB2, SOX2, NEDD4, TNFRSF8, CITED2, DTL, ER81, NOS1, DEAF1, CNGA2, CDH8, MME, GTF2H5, HR1B, SERPINE2, EDN1, FAM175B Oxidative/Metabolic/Environmental Stress Mashaly et al. 2004 [92], Mujahid et al. 2005 [16]
  GO:0004672 Protein kinase activity CDC42BPB, DCLK1, PRKCA, HIPK3, VRK1, ROR1, TRIB2, TGFBR3, TGFBR2, LATS2, ACVR2A, NUAK1, CDC7, ULK1, CDC2L1, PEAK1, JAK1, RPS6KC1, PRKD1 Oxidative/Metabolic/Environmental Stress UniProt [67], Jenuth 2000 [69, 77]