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Table 2 Results of Bivariate GWAS Analyses for C-Reactive Protein and HDL-Cholesterol Levels

From: Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation

SNP Chromosome Position Effect Allele C-reactive protein HDL-cholesterol Pleiotropy significance Gene
Beta P-value Beta P-value
rs12742376 1 27157782 T −0.027 1.7 × 10−2 −0.046 2.8 × 10−7 1.4 × 10−8 C1orf172
rs4660293 1 39800767 A −0.044 1.2 × 10−9 0.034 4.0 × 10−10 3.1 × 10−15 PABPC4
rs646776 1 109620053 T −0.018 1.8 × 10−2 −0.033 6.4 × 10−8 3.2 × 10−9 CELSR2
rs7621025 3 137754936 T 0.028 1.7 × 10−4 0.026 4.1 × 10−6 1.2 × 10−9 STAG1
rs9378212 6 32553669 T 0.027 4.9 × 10−5 0.021 8.1 × 10−6 6.7 × 10−10 HLA-DRA
rs1936797 6 127474350 A 0.022 2.8 × 10−3 0.022 9.9 × 10−7 6.7 × 10−9 RSPO3
rs13244268 7 72549779 T 0.054 2.6 × 10−8 −0.045 1.3 × 10−9 1.2 × 10−13 BAZ1B
rs9987289 8 9220768 A −0.079 2.1 × 10−12 −0.083 6.4 × 10−25 1.2 × 10−39 PPP1R3B
rs4871137 8 121937732 T −0.021 2.2 × 10−3 −0.026 5.6 × 10−6 3.3 × 10−8 SNTB1
rs10761731 10 64697616 A 0.023 2.7 × 10−4 −0.025 2.5 × 10−7 2.2 × 10−8 JMJD1C
rs174546 11 61326406 T −0.017 1.2 × 10−2 −0.048 2.6 × 10−22 1.6 × 10−24 FADS1
rs1077834 15 56510771 T −0.016 4.0 × 10−2 −0.114 9.6 × 10−84 2.5 × 10−87 LIPC
rs1558902 16 52361075 A 0.032 2.0 × 10−6 −0.021 4.6 × 10−6 5.0 × 10−9 FTO
rs711752 16 55553712 A 0.016 1.8 × 10−2 0.192 2.1 × 10−297 4.3 × 10−308 CETP
rs17688076 16 66843928 A 0.019 4.9 × 10−2 0.070 3.9 × 10−22 1.8 × 10−23 LYPLA3
rs11874381 18 45457406 A 0.013 4.9 × 10−2 0.038 1.2 × 10−14 1.0 × 10−15 LIPG
rs12967135 18 56000003 A 0.029 1.2 × 10−4 −0.036 6.6 × 10−9 4.3 × 10−10 MC4R
rs4420638 19 50114786 A 0.240 1.0 × 10−129 0.071 4.4 × 10−21 2 × 10−164 APOC1
rs1800961 20 42475778 T −0.120 2.4 × 10−11 −0.129 1.1 × 10−15 3.9 × 10−28 HNF4A
rs6065906 20 43987422 T 0.036 5.9 × 10−6 0.058 1.9 × 10−22 5.1 × 10−29 PLTP
  1. Abbreviations: SNP single nucleotide polymorphism
  2. For both CRP and the lipid phenotype, the effect estimates are according to the original GWAS
  3. Chromosome and position are in NCBI genome build 36
  4. β coefficient for CRP represents 1-unit change in the natural log–transformed CRP (mg/L) per copy increment in the coded allele
  5. Beta coefficient for HDL-cholesterol represents 1-unit change in the standardized HDL-cholesterol levels per copy increment in the coded allele