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Table 2 Results of Bivariate GWAS Analyses for C-Reactive Protein and HDL-Cholesterol Levels

From: Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation

SNP

Chromosome

Position

Effect

Allele

C-reactive protein

HDL-cholesterol

Pleiotropy significance

Gene

Beta

P-value

Beta

P-value

rs12742376

1

27157782

T

−0.027

1.7 × 10−2

−0.046

2.8 × 10−7

1.4 × 10−8

C1orf172

rs4660293

1

39800767

A

−0.044

1.2 × 10−9

0.034

4.0 × 10−10

3.1 × 10−15

PABPC4

rs646776

1

109620053

T

−0.018

1.8 × 10−2

−0.033

6.4 × 10−8

3.2 × 10−9

CELSR2

rs7621025

3

137754936

T

0.028

1.7 × 10−4

0.026

4.1 × 10−6

1.2 × 10−9

STAG1

rs9378212

6

32553669

T

0.027

4.9 × 10−5

0.021

8.1 × 10−6

6.7 × 10−10

HLA-DRA

rs1936797

6

127474350

A

0.022

2.8 × 10−3

0.022

9.9 × 10−7

6.7 × 10−9

RSPO3

rs13244268

7

72549779

T

0.054

2.6 × 10−8

−0.045

1.3 × 10−9

1.2 × 10−13

BAZ1B

rs9987289

8

9220768

A

−0.079

2.1 × 10−12

−0.083

6.4 × 10−25

1.2 × 10−39

PPP1R3B

rs4871137

8

121937732

T

−0.021

2.2 × 10−3

−0.026

5.6 × 10−6

3.3 × 10−8

SNTB1

rs10761731

10

64697616

A

0.023

2.7 × 10−4

−0.025

2.5 × 10−7

2.2 × 10−8

JMJD1C

rs174546

11

61326406

T

−0.017

1.2 × 10−2

−0.048

2.6 × 10−22

1.6 × 10−24

FADS1

rs1077834

15

56510771

T

−0.016

4.0 × 10−2

−0.114

9.6 × 10−84

2.5 × 10−87

LIPC

rs1558902

16

52361075

A

0.032

2.0 × 10−6

−0.021

4.6 × 10−6

5.0 × 10−9

FTO

rs711752

16

55553712

A

0.016

1.8 × 10−2

0.192

2.1 × 10−297

4.3 × 10−308

CETP

rs17688076

16

66843928

A

0.019

4.9 × 10−2

0.070

3.9 × 10−22

1.8 × 10−23

LYPLA3

rs11874381

18

45457406

A

0.013

4.9 × 10−2

0.038

1.2 × 10−14

1.0 × 10−15

LIPG

rs12967135

18

56000003

A

0.029

1.2 × 10−4

−0.036

6.6 × 10−9

4.3 × 10−10

MC4R

rs4420638

19

50114786

A

0.240

1.0 × 10−129

0.071

4.4 × 10−21

2 × 10−164

APOC1

rs1800961

20

42475778

T

−0.120

2.4 × 10−11

−0.129

1.1 × 10−15

3.9 × 10−28

HNF4A

rs6065906

20

43987422

T

0.036

5.9 × 10−6

0.058

1.9 × 10−22

5.1 × 10−29

PLTP

  1. Abbreviations: SNP single nucleotide polymorphism
  2. For both CRP and the lipid phenotype, the effect estimates are according to the original GWAS
  3. Chromosome and position are in NCBI genome build 36
  4. β coefficient for CRP represents 1-unit change in the natural log–transformed CRP (mg/L) per copy increment in the coded allele
  5. Beta coefficient for HDL-cholesterol represents 1-unit change in the standardized HDL-cholesterol levels per copy increment in the coded allele
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BMC Genomics

ISSN: 1471-2164

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