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Table 4 Results of Bivariate GWAS Analyses for C-Reactive Protein and Total Cholesterol Levels

From: Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation

SNP Chromosome Position Effect Allele C-reactive protein Total cholesterol Pleiotropy significance Gene
Beta P-value Beta P-value
rs469772 1 91302893 T −0.042 1.6 × 10−7 −0.020 1.5 × 10−3 1.5 × 10−8 ZNF644
rs629301 1 109619829 T −0.017 2.8 × 10−2 0.149 5.8 × 10−131 5.7 × 10−132 CELSR2
rs17597773 1 219121384 C 0.020 7.5 × 10−3 −0.031 7.1 × 10−8 6.6 × 10−9 HLX
rs661955 1 232909479 C −0.021 1.7 × 10−3 0.036 1.0 × 10−12 2.2 × 10−14 IRF2BP2
rs1260326 2 27584444 T 0.089 1.7 × 10−42 0.055 7.3 × 10−27 2.6 × 10−63 GCKR
rs4148191 2 43896408 A −0.050 2.5 × 10−4 −0.054 1.1 × 10−6 3.7 × 10−09 ABCG5
rs6734238 2 113557501 A −0.047 4.8 × 10−13 0.023 1.2 × 10−5 5.8 × 10−17 IL1F10
rs4703642 5 74297918 A 0.018 3.0 × 10−3 −0.033 2.0 × 10−11 7.3 × 10−13 GCNT4
rs577272 6 31945942 A 0.020 1.1 × 10−3 0.026 2.3 × 10−7 1.6 × 10−8 SLC44A4
rs2858310 6 32776301 A 0.026 8.7 × 10−5 0.033 3.3 × 10−10 3.8 × 10−12 HLA-DQB1
rs3822857 6 116420624 C −0.032 2.7 × 10−6 −0.033 4.7 × 10−9 2.1 × 10−12 FRK
rs6951245 7 1024719 A 0.03 5.5 × 10−4 0.037 6.1 × 10−8 2.6 × 10−9 C7orf50
rs2126259 8 9222556 T −0.072 5.7 × 10−12 −0.085 9.0 × 10−24 1.4 × 10−31 PPP1R3B
rs11220463 11 125753421 A 0.032 2.8 × 10−3 −0.057 2.1 × 10−11 7.3 × 10−13 ST3GAL4
rs1183910 12 119905190 A −0.151 4.6 × 10−113 0.040 5.2 × 10−14 8.2 × 10−128 HNF1A
rs340025 15 58695599 T −0.036 8.3 × 10−9 0.015 2.4 × 10−3 2.5 × 10−10 RORA
rs1529711 19 10884434 T 0.030 8.4 × 10−4 0.038 6.3 × 10−7 3.4 × 10−8 CARM1
rs2228603 19 19190924 T 0.036 2.9 × 10−3 −0.118 4.3 × 10−34 1.1 × 10−35 NCAN
rs4420638 19 50114786 A 0.240 1.0 × 10−129 −0.184 5.2 × 10−111 3.8 × 10−249 APOC1
rs1800961 20 42475778 T −0.120 2.4 × 10−11 −0.118 5.7 × 10−13 1.0 × 10−20 HNF4A
  1. Abbreviations: SNP single nucleotide polymorphism
  2. For both CRP and the lipid phenotype, the effect estimates are according to the original GWAS
  3. Chromosome and position are in NCBI genome build 36
  4. Beta coefficient for total cholesterol represents 1-unit change in the standardized total cholesterol levels per copy increment in the coded allele
  5. β coefficient for CRP represents 1-unit change in the natural log–transformed CRP (mg/L) per copy increment in the coded allele