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Table 4 Results of Bivariate GWAS Analyses for C-Reactive Protein and Total Cholesterol Levels

From: Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation

SNP

Chromosome

Position

Effect Allele

C-reactive protein

Total cholesterol

Pleiotropy significance

Gene

Beta

P-value

Beta

P-value

rs469772

1

91302893

T

−0.042

1.6 × 10−7

−0.020

1.5 × 10−3

1.5 × 10−8

ZNF644

rs629301

1

109619829

T

−0.017

2.8 × 10−2

0.149

5.8 × 10−131

5.7 × 10−132

CELSR2

rs17597773

1

219121384

C

0.020

7.5 × 10−3

−0.031

7.1 × 10−8

6.6 × 10−9

HLX

rs661955

1

232909479

C

−0.021

1.7 × 10−3

0.036

1.0 × 10−12

2.2 × 10−14

IRF2BP2

rs1260326

2

27584444

T

0.089

1.7 × 10−42

0.055

7.3 × 10−27

2.6 × 10−63

GCKR

rs4148191

2

43896408

A

−0.050

2.5 × 10−4

−0.054

1.1 × 10−6

3.7 × 10−09

ABCG5

rs6734238

2

113557501

A

−0.047

4.8 × 10−13

0.023

1.2 × 10−5

5.8 × 10−17

IL1F10

rs4703642

5

74297918

A

0.018

3.0 × 10−3

−0.033

2.0 × 10−11

7.3 × 10−13

GCNT4

rs577272

6

31945942

A

0.020

1.1 × 10−3

0.026

2.3 × 10−7

1.6 × 10−8

SLC44A4

rs2858310

6

32776301

A

0.026

8.7 × 10−5

0.033

3.3 × 10−10

3.8 × 10−12

HLA-DQB1

rs3822857

6

116420624

C

−0.032

2.7 × 10−6

−0.033

4.7 × 10−9

2.1 × 10−12

FRK

rs6951245

7

1024719

A

0.03

5.5 × 10−4

0.037

6.1 × 10−8

2.6 × 10−9

C7orf50

rs2126259

8

9222556

T

−0.072

5.7 × 10−12

−0.085

9.0 × 10−24

1.4 × 10−31

PPP1R3B

rs11220463

11

125753421

A

0.032

2.8 × 10−3

−0.057

2.1 × 10−11

7.3 × 10−13

ST3GAL4

rs1183910

12

119905190

A

−0.151

4.6 × 10−113

0.040

5.2 × 10−14

8.2 × 10−128

HNF1A

rs340025

15

58695599

T

−0.036

8.3 × 10−9

0.015

2.4 × 10−3

2.5 × 10−10

RORA

rs1529711

19

10884434

T

0.030

8.4 × 10−4

0.038

6.3 × 10−7

3.4 × 10−8

CARM1

rs2228603

19

19190924

T

0.036

2.9 × 10−3

−0.118

4.3 × 10−34

1.1 × 10−35

NCAN

rs4420638

19

50114786

A

0.240

1.0 × 10−129

−0.184

5.2 × 10−111

3.8 × 10−249

APOC1

rs1800961

20

42475778

T

−0.120

2.4 × 10−11

−0.118

5.7 × 10−13

1.0 × 10−20

HNF4A

  1. Abbreviations: SNP single nucleotide polymorphism
  2. For both CRP and the lipid phenotype, the effect estimates are according to the original GWAS
  3. Chromosome and position are in NCBI genome build 36
  4. Beta coefficient for total cholesterol represents 1-unit change in the standardized total cholesterol levels per copy increment in the coded allele
  5. β coefficient for CRP represents 1-unit change in the natural log–transformed CRP (mg/L) per copy increment in the coded allele
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BMC Genomics

ISSN: 1471-2164

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