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Table 2 Benchmark of KinMutRF respect to other methods

From: KinMutRF: a random forest classifier of sequence variants in the human protein kinase superfamily

Method Accuracy Precision Recall F-score MCC
MutationTaster 0.56 0.38 0.96 0.55 0.36
SIFT 0.68 0.45 0.81 0.58 0.39
Polyphen2:HDIV 0.66 0.44 0.90 0.59 0.42
LRT 0.65 0.45 0.87 0.59 0.39
MutationAssessor 0.76 0.55 0.66 0.60 0.43
CADD 0.76 0.54 0.77 0.64 0.48
Polyphen2:HVAR 0.64 0.53 0.85 0.65 0.50
FATHMM 0.82 0.69 0.63 0.66 0.54
VEST 0.87 0.74 0.82 0.78 0.69
KinMutRF 0.88 0.82 0.75 0.78 0.68
  1. Prediction performance in a 10-fold cross-validation experiment on the 3689 kinase variants for which UniProt provides a characterization of pathogenicity. In bold, the best score for each performance measure