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Table 1 Performance of INPS3D and other state-of-the-art predictors

From: Large scale analysis of protein stability in OMIM disease related human protein variants

Method

Cross-validation (2648 variations on 132 proteins)

Blind test set (351 variations on 60 proteins)

Blind test set (42 variations on P53 protein)

INPSb

0.53/1.29a

0.68/1.26a

0.71/1.49a

INPS3D

0.58/1.20a

0.72/1.15a

0.76/1.35a

MAESTROc

0.63/1.17a

0.71/1.16a

0.44/1.71a,e

mCSMd

0.51/1.26a

0.67/1.19a

0.68/1.40a

  1. aPearson’s correlation coefficient/standard error (kcal/mol)
  2. Data are from b[15]; c[13]; d[12], ethis work, respectively