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Table 3 Relation between thermodynamic properties and structural properties in proteins with biologically functional multimeric assembly

From: Large scale analysis of protein stability in OMIM disease related human protein variants

Disease-related variations

RSA ≥ 0.20

RSA < 0.20

|ΔΔG| ≤ 1

660 (28.5 %) Monomera 465

650 (28.0 %) Monomera 24

550 (25.0 %) Complexa 421

760 (31.5 %) Complexa 68

|ΔΔG| > 1

213 (9.2 %) Monomera 152

793 (34.2 %) Monomera 24

196 (8.5 %) Complexa 140

810 (35.0 %) Complexa 36

Polymorphic variations

  

|ΔΔG| ≤ 1

198 (55.6 %) Monomera 131

84 (23.6 %) Monomera 5

186 (52.2 %) Complexa 119

96 (27.0 %) Complexa 17

|ΔΔG| > 1

29 (8.1 %) Monomera 21

45 (12.6 %) Monomera 9

29 (8.1 %) Complexa 21

45 (12.6 %) Complexa 9

  1. aNumber of residue predicted to be part of a protein-protein interaction patch. 2316 disease related variations and 356 polymorphic variations in 191 proteins. Predictions of INPS-3D and PRED-PPI are independent of the assembly state. RSA values were independently estimated on the monomeric and the complex structures