Fig. 1

Statistics of the mutation distribution in different tumor types in COSMIC and an overview of HotDriver. a Providing a mutational profile from a specific tumor type, the variants were classified into 20 mutation subtypes, then the mutation subtype-specific mutations rates were computed for each investigated genes and the significant level of each amino acid position on the corresponding genes was calculated. After that, the significant level of each amino acid position was calculated by combining p values from different mutation subtypes using Fisher’s method, and an adjusted p value was computed for each amino acid position. b The mutation rate of 20 mutation subtypes in 17 main tumor types of COSMIC v71 whole genome and whole exome sequencing data