Fig. 3

Mutational signatures of hotspot mutations in 16 tumor types. The x-axis represents the tumor types and the y-axis represent the 8 types of sequence contexts (concatenating missense, nonsense and silent mutations). Each bar represents the percentage of specific sequence contexts under which the hotspot mutations happen. In each tumor type, the addition of the percentages of different sequence contexts might be larger than 1, because one or more types of mutations may happen on a single hotspot driver mutation site