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Fig. 4 | BMC Genomics

Fig. 4

From: Hotspot mutations delineating diverse mutational signatures and biological utilities across cancer types

Fig. 4

Functional implications of hotspot mutations in RNA and protein expression. a In BRCA, tumor samples with G108 deletion hotspot mutations in TP53 exhibit lower TP53 RNA expression than those with non-hotspot mutations and without TP53 mutations. In contrast, tumor samples with missense hotspot mutations (R175, Y220, R248 and R273) in TP53 show higher TP53 RNA and protein expression. In READ, tumor samples with R175 missense mutations show higher TP53 RNA and protein expression than those with non-hotspot mutations and without TP53 mutations, while R213 nonsense mutations has the opposite effect. b In BRCA, tumor samples with H1047 missense hotspot mutations in PIK3CA show higher AKT pT308 and pS473 levels than those with no mutations in PIK3CA, while in COAD, tumor samples with E542 missense hotspot mutations in PIK3CA show higher AKT pT308 and pS473 levels than those with no mutations in PIK3CA. * indicates p < 0.05 and ** indicates p < 0.001 between samples with specified hotspot mutations and samples with non-hotspot mutations in examined gene; # indicates p < 0.05 and ## indicates p < 0.001 between samples with specified hotspot mutations and samples without mutations in examined gene

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