Fig. 5

Functional implications of hotspot mutations in drug sensitivity. a Cancer cells with NRAS Q61 or KRAS G12 missense hotspot mutations exhibit higher sensitivity to MEK inhibitors (PD-0325901 and AZD6244) than those with non-hotspot mutations or without any mutations in NRAS or KRAS. b Cancer cells with MAP3K4 A1199 deletion hotspot mutations exhibit lower sensitivity to different EGFR inhibitors (Erlotinib, Lapatinib, TKI258 and AZD0530) than those with non-hotspot mutations or without any mutations in MAP3K4. * indicates p < 0.05 between samples with specified hotspot mutations and samples with non-hotspot mutations in examined gene; # indicates p < 0.05 between samples with specified hotspot mutations and samples without mutations in examined gene