Fig. 6

Prevalence of hotspot mutations in different TCGA cancer types and their functional implications. a In TP53, hotspot mutations are differentially prevalent in different tumor types, indicating their differential functions. b In BRCA, samples with NR1H2 Q175 in-frame insertion hotspot mutations have significantly lower NR1H2 expression compared to samples with NR1H2 non-hotspot mutations. c In BRCA, sample with GATA3 P409 insertion hotspot mutations have obviously higher GATA3 compared to samples without GATA3 mutation. * indicates p < 0.05 between samples with specified hotspot mutations and samples with non-hotspot mutations in examined gene; # indicates p < 0.05 between samples with specified hotspot mutations and samples without mutations in examined gene