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Fig. 3 | BMC Genomics

Fig. 3

From: Genome-wide alteration of 5-hydroxymenthylcytosine in a mouse model of Alzheimer’s disease

Fig. 3

Genomic features of 5hmC peaks in hippocampus between WT and DTg mice. a-b 6115, 39,606, 8335, and 19,977 of 5hmC peaks were called from 12- and 67-week-old WT and age-matched DTg mice biological replicates, respectively. 5518 peaks overlapped between 12- and 67-week-old WT mice. 5289 peaks overlapped between 12- and 67-week-old DTg mice. 3011 peaks overlapped between 12-week-old WT and DTg mice. 15,002 peaks overlapped between 67-week-old WT and DTg mice. c Genome-wide 5hmC reads were counted within each 10-kb bin in WT_12 WK and DTg_12WK mice genome. 5hmC levels were not significantly different between adult WT and DTg mice. d Genome-wide 5hmC reads densities were higher in WT mice than in DTg mice. e, f, g and h Normalized 5hmC read densities on transcription end sites (TESs), transcription start sites (TSSs), gene bodies, and CpG islands. The enrichment of 5hmC significantly decreased in adult and aged DTg mice compared to age matched WT mice, but no significant difference was observed at TSS, TES, and CpG islands. t-test, p < 0.01

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