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Table 6 Apoptosis and cell proliferation target genes

From: A de novo transcriptome analysis shows that modulation of the JAK-STAT signaling pathway by salmonid alphavirus subtype 3 favors virus replication in macrophage/dendritic-like TO-cells

Gene name

Abbr

Unigenes

NCBI

KEGG

TO-VS-SAV3

TO-VS-IFN/SAV3

     

Log2 (Fold change)

Reg

P-value

Log2 (Fold change)

Reg

P-value

A: Stat pathway genes

 Signal transducing adaptor molecule 2

STAM2

CL86.2

NP_001007370.1

K04705

-1.51

Down

1.76e-12

   

 Interferon regulatory factor 9

IRF9

CL11337.2

NP_001167190.1

K04693

   

1.65

Up

1.26e-13

 CREB binding protein

CBP

CL7696.2

AAY85296.1

K04498

-2.67

Down

1.14e-06

   

 Threonine-protein kinase pim-1-like

Pim-1

CL9459.2

XP_003449193.1

K04702

-1.11

Down

2.38e-55

1.07

Up

5.80e-90

 Threonine-protein kinase pim-3-like

Pim-3

CL1163.1

XP_003445092.1

K08807

-1.63

Down

9.75e-179

   

B: MAPK Signaling pathway

 Protein tyrosine phosphatase, non-receptor 11

PTPN11

Unig19725

XP_003965393.1

K07293

-2.25

Down

2.21e-3

   

 Son of sevenless homolog 1

SOS1

CL9403.1

XP_003216158.1

K03099

-2.66

Down

3.28e-10

-1.06

Down

1.17e-3

 Son of sevenless homolog 2

SOS2

Unig28623

XP_003443018.1

K03099

-2.57

Down

5.88e-07

   

 Transcriptional regulator Myc-2

Myc-2

Unig13199

NP_001167287.1

K04377

-2.16

Down

3.244e-07

1.11

Up

1.03e-05

 G1/S-specific cyclin-D1

CycD1

CL11123.1

NP_001158863.1

K04503

-1.33

Down

3.33e-05

   

 G1/S-specific cyclin-D2

CycD2

CL3895.1

ACO14329.1

K10151

-2.23

Down

1.35e-168

   

 Apoptosis regulator Bcl-X

BcIXL

CL2019.1

ACI68003.1

K04070

-1.30

Down

1.21e-38

   

 Sprouty-related, EVH1 domain containing

Sprouty

CL10970.1

XP_003456564.1

K04703

-1.84

Down

7.73e-62

   

C: PI3K-AKT pathway

 Akt RAC-beta serine/threonine-protein kinase

AKT

CL4020.1

ACY30363.1

K04456

-1.59

Down

3.83e-16

   

 Phosphatidylinositol-4,5-bisphosphate 3-kinase

PIK3CA

Unig30697

NP_998471.1

K00922

-1.64

Down

2.0e-5

-1.21

Down

4.84e-3

D: Other genes

 E3 ubiquitin-protein ligase CBL-B

CBL-B

Unig24091

XP_001921961.3

K04707

   

1.80

Up

3.48e-07