Fig. 4

Clustering of bla _NDM-positive plasmids. a Neighbor-Joining tree of the 7 bla _NDM clusters. Branches of each cluster are colored according to the same color scheme as Fig. 3. The tree is rooted using outgroup in black. Branch lengths were Euclidean distances calculated from similarity scores and are reflective of the similarity of plasmid gene composition and the similarity of shared genes. b Table showing the identity (PLASMID), bacterial host (HOST), specimen type (SPECIMEN), date of collection (DOC), geographical sampling location (LOC), travel history (HISTORY) and incompatibility group (INC) for each plasmid. Abbreviations: AB, Acinetobacter baumannii; AI, A.iwoffii; AP, A. pittii; AS, A. soli; CF, Citrobacter freundii, EN, Enterobacter cloacae; EC, Escherichia coli; KP, Klebsiella pneumoniae; RP, Roultella planticola. c The matrix displays the resistance genetic determinants identified in the corresponding plasmid genome. A black-shaded box indicates a positive genotypic trait conferring resistances, the antibiotic classes of which are indicated by the text at the top of the column. Resistance determinants against the following antibiotics were identified: β-lactam, BETA; aminoglycoside, AMINO; tetracycline, TET; sulphonamide; SUL; phenicol; PHE. Abbreviations: A, APH; C, AAC; D, AAD; K, KPC; M, CMY; O, OXA; S, SHV; R, RMT; X, CTX. Presence of bla _NDM-1 was shaded red and bla _NDM-5 shaded green