Fig. 6

Circos plot of gene fitness, regulons, and library insertion metrics. The outer ring (ring 1) illustrates gene fitness categorizations from consensus data generated by all pooled libraries and time points. The next concentric ring (ring 2) shows all genes that are predicted to participate in an RNA-based (blue text in legend) or transcription factor-based (black text in legend) regulon. Genes that participate in multiple regulons are black. Essential or critical genes that participate in a regulon are tiled in the next ring (ring 3; if an essential or critical gene participates in multiple regulons, the appropriately colored tiles are stacked). The inner three rings (4–6) show unique transposon insertions per gene for each of the three pooled time points