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Table 2 Evolution of docetaxel resistance in MDA-MB-231 cells

From: The stepwise evolution of the exome during acquisition of docetaxel resistance in breast cancer cells

Docetaxel concentration Passage numbers Days at given concentrationa Subpopulation for analysis Doubling time (Days)
Parental - - MDAPAR 1.1
10 pM 1–3 16   
30 pM 4–6 13   
90 pM 7–9 18   
270 pM 10–12 14 MDASUB-0.27nM 1.4
810 pM 13–15 20   
1.2 nM 16–18 14   
1.8 nM 19–21 23   
2.25 nM 22–24 16   
2.8 nM 25–27 13   
3.5 nM 28–30 18   
5 nM 31–33 22 MDASUB-5nM 1.6
15 nM 34–36 35 MDASUB-15nM 2.8
45 nM 37–39 25   
60 nM 40–42 28   
80 nM 43–45 25   
100 nM 46–48 18 MDASUB-100nM 1.0
120 nM 49–51 26   
150 nM 52-   MDARES.150nM 1.0
  1. aNumbers in bold indicate concentration levels at which the cells took more than the average 20 days per concentration step to recover and go through 3 passages