The stepwise evolution of the exome during acquisition of docetaxel resistance in breast cancer cells

BMC Genomics

Table 2 Evolution of docetaxel resistance in MDA-MB-231 cells

Docetaxel concentration	Passage numbers	Days at given concentration^a	Subpopulation for analysis	Doubling time (Days)
Parental	-	-	MDA_PAR	1.1
10 pM	1–3	16
30 pM	4–6	13
90 pM	7–9	18
270 pM	10–12	14	MDA_SUB-0.27nM	1.4
810 pM	13–15	20
1.2 nM	16–18	14
1.8 nM	19–21	23
2.25 nM	22–24	16
2.8 nM	25–27	13
3.5 nM	28–30	18
5 nM	31–33	22	MDA_SUB-5nM	1.6
15 nM	34–36	35	MDA_SUB-15nM	2.8
45 nM	37–39	25
60 nM	40–42	28
80 nM	43–45	25
100 nM	46–48	18	MDA_SUB-100nM	1.0
120 nM	49–51	26
150 nM	52-		MDA_RES.150nM	1.0

^aNumbers in bold indicate concentration levels at which the cells took more than the average 20 days per concentration step to recover and go through 3 passages

ISSN: 1471-2164