Table 5 Variant types: acquired and selected variants in MCF-7 sub-lines
Consequence | MCF-7 | MCF-7 | MCF-7 | MCF-7 | MCF-7 |
|---|---|---|---|---|---|
SUB-0.27nM | SUB-1.2nM | SUB-7.5nM | SUB-45nM | RES-65nM | |
3 prime UTR variant | 26 | 6 | 2 | 2 | 29 |
5 prime UTR variant | 6 | 6 | 1 | 2 | 21 |
NMD transcript variant | 70 | 33 | 3 | 14 | 128 |
TF binding site variant | 0 | 0 | 0 | 0 | 0 |
Downstream gene variant | 169 | 85 | 29 | 38 | 236 |
Feature elongation | 29 | 2 | 8 | 22 | 20 |
Feature truncation | 63 | 38 | 7 | 18 | 75 |
Frameshift variant | 0 | 1 | 0 | 0 | 0 |
Inframe insertion | 0 | 0 | 0 | 0 | 0 |
Intron variant | 618 | 228 | 70 | 136 | 656 |
Mature miRNA variant | 0 | 0 | 0 | 0 | 0 |
Missense variant | 44 | 55 | 0 | 12 | 85 |
Nc transcript variant | 182 | 89 | 12 | 58 | 203 |
Non coding exon variant | 45 | 36 | 3 | 13 | 75 |
Regulatory region variant | 27 | 13 | 5 | 12 | 54 |
Splice acceptor variant | 0 | 0 | 0 | 0 | 12 |
Splice region variant | 12 | 5 | 1 | 6 | 17 |
Stop gained | 0 | 4 | 0 | 0 | 10 |
Synonymous variant | 35 | 24 | 3 | 5 | 68 |
Upstream gene variant | 95 | 66 | 13 | 38 | 195 |
Total | 1421 | 691 | 157 | 376 | 1884 |