Skip to main content

Table 6 Variant types: acquired and selected variants in MDA-MB-231 sub-lines

From: The stepwise evolution of the exome during acquisition of docetaxel resistance in breast cancer cells

Consequence MDA MDA MDA MDA MDA
SUB-0.27nM SUB-5nM SUB-15nM SUB-100nM RES-150nM
3 prime UTR variant 25 8 1 3 28
5 prime UTR variant 6 7 1 0 14
NMD transcript variant 68 27 4 20 115
TF binding site variant 1 0 0 0 0
Downstream gene variant 197 97 14 40 361
Feature elongation 47 11 18 30 48
Feature truncation 59 14 0 13 29
Frameshift variant 0 0 0 1 0
Inframe insertion 1 0 0 0 0
Intron variant 741 224 51 97 769
Mature miRNA variant 0 0 0 1 0
Missense variant 18 43 4 9 130
Nc transcript variant 202 78 16 30 228
Non coding exon variant 57 37 7 5 74
Regulatory region variant 32 11 1 8 42
Splice acceptor variant 0 0 0 0 0
Splice region variant 22 15 1 2 45
Stop gained 0 2 0 0 9
Synonymous variant 60 30 0 16 61
Upstream gene variant 169 62 5 17 170
Total 1705 666 123 292 2123