Table 6 Variant types: acquired and selected variants in MDA-MB-231 sub-lines
Consequence | MDA | MDA | MDA | MDA | MDA |
|---|---|---|---|---|---|
SUB-0.27nM | SUB-5nM | SUB-15nM | SUB-100nM | RES-150nM | |
3 prime UTR variant | 25 | 8 | 1 | 3 | 28 |
5 prime UTR variant | 6 | 7 | 1 | 0 | 14 |
NMD transcript variant | 68 | 27 | 4 | 20 | 115 |
TF binding site variant | 1 | 0 | 0 | 0 | 0 |
Downstream gene variant | 197 | 97 | 14 | 40 | 361 |
Feature elongation | 47 | 11 | 18 | 30 | 48 |
Feature truncation | 59 | 14 | 0 | 13 | 29 |
Frameshift variant | 0 | 0 | 0 | 1 | 0 |
Inframe insertion | 1 | 0 | 0 | 0 | 0 |
Intron variant | 741 | 224 | 51 | 97 | 769 |
Mature miRNA variant | 0 | 0 | 0 | 1 | 0 |
Missense variant | 18 | 43 | 4 | 9 | 130 |
Nc transcript variant | 202 | 78 | 16 | 30 | 228 |
Non coding exon variant | 57 | 37 | 7 | 5 | 74 |
Regulatory region variant | 32 | 11 | 1 | 8 | 42 |
Splice acceptor variant | 0 | 0 | 0 | 0 | 0 |
Splice region variant | 22 | 15 | 1 | 2 | 45 |
Stop gained | 0 | 2 | 0 | 0 | 9 |
Synonymous variant | 60 | 30 | 0 | 16 | 61 |
Upstream gene variant | 169 | 62 | 5 | 17 | 170 |
Total | 1705 | 666 | 123 | 292 | 2123 |