From: Systematic identification and analysis of frequent gene fusion events in metabolic pathways
Metabolism area | Enzyme roles | EC numbers | SEED gene identifier | Metabolite involved | References |
---|---|---|---|---|---|
Aromatic amino acids | Cyclohexadienyl dehydratase/Periplasmic chorismate mutase I precursor | 4.2.1.51/5.4.99.5 | fig|325240.9.peg.4134 | Prephenate | |
Indole-3-glycerol phosphate synthase/Phosphoribosylanthranilate isomerase | 4.1.1.48/5.3.1.24 | fig|991999.3.peg.2431 | 1-(2-Carboxyphenylamino)-1-deoxyribulose 5-phosphate | [77] | |
Histidine | Phosphoribosyl-AMP cyclohydrolase/Phosphoribosyl-ATP pyrophosphatase | 3.5.4.19/3.6.1.31 | fig|751585.3.peg.1763 | Phosphoribosyl-AMP | [78] |
Glyoxalate | Isocitrate lyase / Malate synthase | 4.1.3.1/2.3.3.9 | fig|404589.10.peg.3099 | Glyoxalate | |
Sulfur | Adenylylsulfate kinase/Sulfate adenylyltransferase subunit 1 | 2.7.1.25/2.7.7.4 | fig|349163.14.peg.1814 | Adenosine 5′-phosphosulfate | [82] |
Folate | Aminodeoxychorismate lyase/Para-aminobenzoate synthase, aminase component | 4.1.3.38/2.6.1.85 | fig|257309.4.peg.1776 | 4-Amino-4-deoxychorismate | [83] |
Phosphonate | 2-Aminoethylphosphonate:pyruvate aminotransferase/Phosphonoacetaldehyde hydrolase | 2.6.1.37/3.11.1.1 | fig|691161.5.peg.2163 | Phosphonoacetaldehyde | [84] |
Siderophore | 2,3-Dihydroxybenzoate-AMP ligase/Isochorismatase/Isochorismate synthase | 2.7.7.58/3.3.2.1/5.4.4.2 | fig|306537.3.peg.2089 | Isochorismate | |
Heme and siroheme biosynthesis | Precorrin-2 oxidase/Sirohydrochlorin ferrochelatase / Uroporphyrinogen-III methyltransferase | 1.3.1.76/4.99.1.4/2.1.1.107 | fig|644335.4.peg.2909 | Precorrin 2 | |
Uroporphyrinogen-III methyltransferase/Uroporphyrinogen-III synthase | 2.1.1.107/4.2.1.75 | fig|479834.4.peg.2988 | UroporphyrinogenIII | ||
Porphobilinogen deaminase/Uroporphyrinogen-III synthase | 2.5.1.61/4.2.1.75 | fig|1049939.3.peg.1307 | Hydroxymethylbilane | [92] |