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Table 4 Cases where a fusion of a domain of unknown function to a B vitamin gene led to a functional discovery

From: Systematic identification and analysis of frequent gene fusion events in metabolic pathways

Domain

Vitamin pathway

Molecular function

ref

COG3236

Riboflavin

N-glycosidase

[14]

DUF89

CoA

Phosphatase

[93]

DUF1537

PLP

Kinase

[94]

Tnr3/Nudix

Thiamin

Pyrophosphatase

[13]

COG1058

Niacin

Pyrophosphatase

[95]

Human CoaD

CoA

Adenyl transferase

[10]

TenA-HAD

Thiamin

Hydrolase

unpublished

HAD-IA

Thiamin

Hydrolase

[96]

HAD-IB

Thiamin

Hydrolase

[96]