Psychoactive pharmaceuticals at environmental concentrations induce in vitro gene expression associated with neurological disorders

Kaushik, Gaurav; Xia, Yu; Yang, Luobin; Thomas, Michael A.

doi:10.1186/s12864-016-2784-1

Table 2 Ranked gene list from the valproate treatment (50 most up- and down-regulated)

From: Psychoactive pharmaceuticals at environmental concentrations induce in vitro gene expression associated with neurological disorders

Up-regulated genes					Down-regulated genes
Rank	Genes	Fold change	P-value	Fold change in fish brains	Rank	Genes	Fold change	P-value	Fold change in fish brains
1	OPRK1	4.03	0.000	−0.29	17673	CMKLR1	−2.81	0.000	0.86
2	NEUROG2	3.55	0.000		17672	ADAMTS2	−2.74	0.000	0.09
3	VSNL1	3.19	0.000	2.84	17671	HIST1H4L	−2.67	0.000
4	GALNAC4S-6ST	3.09	0.000	0.96	17670	ELFN1	−2.44	0.000
5	POSTN	2.93	0.000	1.22	17669	COL4A2	−2.39	0.000	−0.42
6	EVX2	2.86	0.000		17668	GREM2	−2.33	0.000
7	SERPINE1	2.69	0.000	−1.45	17667	FLJ45455	−2.32	0.000	0.86
8	ODZ1	2.64	0.000		17666	VCAN	−2.31	0.000
9	DRD5	2.34	0.000	−0.23	17665	SOCS3	−2.29	0.000	0.02
10	CSGALNACT1	2.33	0.001		17664	TGFBI	−2.27	0.000	−1.11
11	HOXD13	2.31	0.000		17663	C11orf53	−2.26	0.000
12	C3orf57	2.29	0.000		17662	SNAI1	−2.17	0.000	−0.82
13	B3GALT1	2.29	0.000		17661	LOC283480	−2.11	0.000
14	SECTM1	2.28	0.001		17660	ID1	−2.05	0.000	0.23
15	PLAU	2.20	0.001		17659	PPP1R9A	−2.03	0.000	−0.05
16	PDE1A	2.19	0.000		17658	LOC646498	−2.02	0.004
17	VIM	2.14	0.000	0.25	17657	RPS16P5	−2.02	0.000
18	MME	2.11	0.000		17656	COL4A1	−1.98	0.000	0.10
19	KCNJ2	2.09	0.000		17655	GLT8D2	−1.98	0.000
20	HS6ST2	2.09	0.000	−0.15	17654	CYP26A1	−1.96	0.000	0.26
21	SNORA42	2.00	0.003		17653	SLC10A1	−1.95	0.004
22	RASEF	1.99	0.000	0.31	17652	PART1	−1.94	0.000
23	APOL6	1.93	0.000		17651	OXTR	−1.89	0.000	1.26
24	NCRNA00164	1.91	0.007		17650	PTPLAD2	−1.84	0.007
25	COLQ	1.91	0.000		17649	C9orf131	−1.83	0.001
26	CACNA2D3	1.90	0.000	0.90	17648	FOS	−1.80	0.000	−0.63
27	DEGS2	1.90	0.000		17647	C9orf135	−1.79	0.009
28	NHS	1.89	0.000		17646	GLP1R	−1.79	0.000
29	PTER	1.89	0.001	0.11	17645	ETS1	−1.79	0.000	−0.79
30	EDIL3	1.87	0.000	−0.41	17644	NXPH3	−1.79	0.000
31	INSM2	1.85	0.000		17643	LOC100128505	−1.79	0.013
32	GFRA3	1.82	0.000		17642	KCTD12	−1.76	0.000	0.49
33	PROKR2	1.82	0.000		17641	ANGPTL4	−1.74	0.000
34	GRM8	1.81	0.001		17640	FOSB	−1.73	0.000
35	TLE4	1.79	0.000		17639	MPPED2	−1.72	0.000	−0.62
36	WNT5A	1.77	0.001	−0.38	17638	C11orf92	−1.71	0.003
37	SMOC2	1.77	0.000	−0.26	17637	WDR38	−1.69	0.001
38	VCAM1	1.76	0.014	0.53	17636	GALNT14	−1.68	0.000	0.03
39	FRMD4B	1.74	0.000	0.10	17635	LOC283143	−1.67	0.002
40	PTRF	1.74	0.000		17634	ACCN1	−1.66	0.002
41	DLK1	1.70	0.000	0.69	17633	C14orf53	−1.66	0.002
42	PTCHD1	1.67	0.001		17632	TAPBPL	−1.65	0.021
43	GPR126	1.66	0.022		17631	NRP1	−1.63	0.000	1.12
44	ANKDD1B	1.65	0.000		17630	BFSP2	−1.63	0.002
45	MOXD1	1.65	0.002	−1.00	17629	SMAD7	−1.63	0.000	0.08
46	FAM111B	1.65	0.000		17628	HOPX	−1.62	0.028
47	LOC728739	1.63	0.002		17627	ERBB4	−1.62	0.000
48	CHRNA10	1.62	0.002		17626	PAPPA2	−1.62	0.000
49	NELL1	1.62	0.000		17625	PCDHGB8P	−1.62	0.011
50	NELL2	1.62	0.000	−0.76	17624	LOC284454	−1.60	0.000

Table representing the list of 50 most up- and down-regulated genes in human neuronal cells treated with the valproate. Genes were ranked based on their expression in fold- change in human cells. P-value represents the significance level of the expression change in the mixture treatment than control. Corresponding fold change of genes in fish brains is also reported in this table, where blank cells represents genes that are not found in the fish microarray chip

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ISSN: 1471-2164

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