Genome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid

BMC Genomics

Table 1 Significant SNPs were scattered across chromosomes 2, 6, 7, 8 and 17, with the majority of the SNPs being on chromosome 6. These 12 SNPs were all significant in both the blood plasma and CSF. Information on the SNPs includes chromosome, reference and alternate allele, minor allele frequency, predicted function, the gene the SNP is found in or near, RegulomeDB score, and the meta-analysis p-values for plasma and CSF

SNP	Chr	Base Pair Position	Major Allele	Minor Allele	MAF	Predicted Function	Gene	RegulomeDB score	Meta-analysis p-value
SNP	Chr	Base Pair Position	Major Allele	Minor Allele	MAF	Predicted Function	Gene	RegulomeDB score	Plasma	CSF
rs12548348	8	70430077	A	G	0.1222	Intronic	SULF1	No Data	6.288e-11	9.841e-26
rs13408093	2	62251682	A	T	0.0699	Intronic	TRIB2	5	6.881e-10	2.119e-25
rs1150703	6	28184260	G	T	0.0919	ncRNA_exonic	TOB2P1	5	3.276e-09	7.011e-26
rs988083	6	28177588	C	T	0.1220	Intergenic	ZNF192P1,TOB2P1	5	3.276e-09	7.011e-26
rs988084	6	28177492	C	T	0.1218	Intergenic	ZNF192P1,TOB2P1	6	3.276e-09	7.011e-26
rs73726888	7	15021811	T	C	0.0893	UTR3	GIMAP7	6	4.209e-09	6.438e-24
rs8073041	17	47498253	T	A	0.0731	Intergenic	PHB,LOC101927207	6	7.87e-09	2.169e-10
rs1150701	6	28183886	A	C	0.1410	ncRNA_exonic	TOB2P1	6	1.184e-08	1.443e-26
rs1150702	6	28184097	A	T	0.1410	ncRNA_exonic	TOB2P1	5	1.184e-08	1.443e-26
rs1233712	6	28193131	G	A	0.1406	UTR5	ZSCAN9	4	1.184e-08	1.443e-26
rs79268972	17	47531241	T	G	0.0749	Intergenic	PHB,LOC101927207	5	2.547e-08	8.169e-12
rs77482998	7	47532356	T	C	0.0665	Intronic	TNS3	5	4.608e-08	7.983e-12

ISSN: 1471-2164