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Table 1 This table includes the 10 most significant SNPs and 13 other significant SNPs that have a RegulomeDB score less than 3, are non-synonymous, a splicing variant, or are located in untranslated regions (UTRs). All 23 SNPs are located in or near the ACPP gene on chromosome 3, which codes for PAP. There were no significant non-synonymous SNPs. The table includes SNP ids, reference and alternate alleles, minor allele frequency, predicted SNP function, and its directions in the Knight ADRC and ADNI data sets. Also included are the p-values from ADNI and Knight ADRC alone, their meta-analysis p-value and their RegulomeDB score, where available

From: Variants in ACPP are associated with cerebrospinal fluid Prostatic Acid Phosphatase levels

SNP Minor Allele Major Allele MAF Predicted Function Direction ADNI p-value Knight ADRC p-value Meta-analysis p-value RegulomeDB score
rs3844501 T G 0.1458 Intergenic ++ 1.972e-13 7.974e-09 1.743e-20 6
rs3762671 T C 0.1060 Intergenic ++ 3.815e-13 3.245e-08 1.515e-19 6
rs11716607 G A 0.0923 Intronic ++ 1.708e-12 3.615e-08 6.397e-19 No Data
rs56158166 T G 0.0921 Intronic ++ 1.708e-12 3.615e-08 6.397e-19 No Data
rs73213842 A T 0.0923 Intergenic ++ 1.708e-12 3.615e-08 6.397e-19 No Data
rs11706024 A G 0.0921 Intergenic ++ 1.708e-12 3.615e-08 6.397e-19 5
rs113143077 A G 0.0923 Intergenic ++ 1.708e-12 3.615e-08 6.397e-19 6
rs17344445 A G 0.0923 Intergenic ++ 1.708e-12 3.615e-08 6.397e-19 6
rs2887519 A G 0.0923 Intergenic ++ 1.708e-12 3.615e-08 6.397e-19 6
rs56073503 A T 0.0921 Intronic ++ 1.708e-12 3.615e-08 6.397e-19 6
rs3889987 T G 0.0913 Intergenic ++ 2.15E-13 4.08E-07 1.77E-18 2a
rs56030168 G A 0.1769 5upstream ++ 2.94E-11 1.34E-06 4.65E-16 2b
rs11714139 A G 0.1232 Intergenic ++ 1.25E-07 4.81E-04 5.41E-10 2b
rs56226080 C G 0.1228 Intergenic ++ 1.25E-07 4.81E-04 5.41E-10 2b
rs73211958 A C 0.1218 Intergenic ++ 1.25E-07 5.11E-4 5.82E-10 2b
rs16839055 T C 0.3081 Intergenic ++ 2.49E-05 2.52E-04 2.55E-08 1f
rs1804136 T G 0.3962 UTR3 ++ 4.80E-05 1.39E-04 2.57E-08 No Data
rs14192 C T 0.3964 UTR3 ++ 4.80E-05 1.39E-04 2.57E-08 5
rs1042330 A G 0.3962 UTR3 ++ 6.49E-05 1.39E-04 3.43E-08 No Data
rs17182812 T C 0.3962 Intronic ++ 6.49E-05 1.39E-04 3.43E-08 1f
rs4257547 G C 0.4113 Intronic ++ 5.19E-05 1.94E-04 3.87E-08 2b
rs11928839 A C 0.3954 Intronic ++ 6.49E-05 1.60E-04 3.93E-08 2b
rs11917521 C T 0.3954 Intronic ++ 6.49E-05 1.60E-04 3.93E-08 2b