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Fig. 4 | BMC Genomics

Fig. 4

From: MBDDiff: an R package designed specifically for processing MBDcap-seq datasets

Fig. 4

Statistical power of MBDDiff, MEDIPS and DESeq for simulated datasets in different scenarios. Bar plot of statistical power for simulated MBDcap-seq datasets with low, intermediate or high level of background noise with 3 number of replicates in each group, 10 % of DM promoters with 2 fold of difference (a); Different levels of background noise but only for highly methylated promoters above 75 % quantile of methylation levels (b); Different levels of background noise but only for lowly methylated promoters below 25 % quantile of methylation levels (c); Bar plot of statistical power for simulated MBDcap-seq datasets with low, intermediate or high level of background noise with 6 number of replicates in each group, 10 % of DM promoters with 2 fold of difference (d); Simulation was carried out 100 times and the average results is used

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