Fig. 5From: MBDDiff: an R package designed specifically for processing MBDcap-seq datasetsGC enrichment assessment. We perform GC enrichment test for all samples processed with MBDCap-seq protocol. a Enrichment score (ES) of 0.25 were detected for a MET sample. The dash lines are two Gaussian mixture models (light dash line for normal human genome GC distribution estimated from 50 bp short reads, and dark dash line for enriched 50 bp reads). ES score is evaluated by using Eq. 1. b ES of 0.33 for a NED sample. Both samples pass the threshold of > 0.20 requirement. In both (a) and (b), blue-line is the empirical density from the actual data, and red-line is the mixture model density. Both figure showed a tight estimationBack to article page