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Table 2 Top 27 rank-ordered T2D relevant proteins

From: Predicting diabetes mellitus genes via protein-protein interaction and protein subcellular localization information

Rank Protein Score Description Diabetes relevance
1 PPARG 85.83 peroxisome proliferator activated Known
    receptor gamma, T2D, susceptibility to  
2 HMGA1 63.99 high mobility group AT-hook 1, Diabetes, Known
    noninsulin-dependent, susceptibility to  
3 HNF4A 60.08 hepatocyte nuclear factor 4 alpha, Known
    Diabetes mellitus, noninsulin-dependent  
4 IRS1 45.12 insulin receptor substrate 1, Diabetes, Known
    noninsulin-dependent  
5 HNF1A 24.21 HNF1 homeobox A, Diabetes, Known
    noninsulin-dependent, 2  
6 AKT2 23.28 v-akt murine thymoma viral Known
    oncogene homolog 2, Diabetes, type II  
7 TCF7L2 20.03 transcription factor 7 like 2, Known
    Diabetes, type 2, susceptibility to  
8 IGF2BP2 17.77 insulin like growth factor 2 Known
    mRNA binding protein 2, Diabetes,  
    noninsulin-dependent, susceptibility to  
9 MAPK8IP1 14.52 mitogen-activated protein kinase 8 Known
    interacting protein 1, Diabetes,  
    noninsulin-dependent  
10 IRS2 12.78 insulin receptor substrate 2, Known
    Diabetes, noninsulin-dependent  
11 NEUROD1 7.03 neurogenic differentiation 1, Known
    Diabetes, noninsulin-dependent  
12 UBC 6.52 ubiquitin C Novel
13 HNF1B 6 HNF1 homeobox B, Diabetes, Known
    noninsulin-dependent  
14 EP300 4 E1A binding protein p300 Novel
15 CREBBP 4 CREB binding protein Novel
16 ESR1 3.47 estrogen receptor 1 Novel
17 AKT1 3.02 v-akt murine thymoma Novel
    viral oncogene homolog 1  
18 NRF1 3.02 NFKB repressing factor Novel
19 PCBD1 3 pterin-4 alpha-carbinolamine dehydratase 1 Novel
20 SP1 3 Sp1 transcription factor Novel
21 HDAC4 3 histone deacetylase 4 Novel
22 YWHAB 2.49 tyrosine 3-monooxygenase/tryptophan Novel
    5-monooxygenase activation protein beta  
23 EGFR 2.47 epidermal growth factor receptor Novel
24 GCK 2.45 glucokinase, Diabetes, noninsulin-dependent, Known
    late onset  
25 ELAVL1 2.45 ELAV like RNA binding protein 1 Novel
26 APP 2.29 amyloid beta precursor protein Novel
27 SUMO2 2.01 small ubiquitin-like modifier 2 Novel