Table 2 Top 27 rank-ordered T2D relevant proteins

1

PPARG

85.83

peroxisome proliferator activated

Known

receptor gamma, T2D, susceptibility to

2

HMGA1

63.99

high mobility group AT-hook 1, Diabetes,

Known

noninsulin-dependent, susceptibility to

3

HNF4A

60.08

hepatocyte nuclear factor 4 alpha,

Known

Diabetes mellitus, noninsulin-dependent

4

IRS1

45.12

insulin receptor substrate 1, Diabetes,

Known

noninsulin-dependent

5

HNF1A

24.21

HNF1 homeobox A, Diabetes,

Known

noninsulin-dependent, 2

6

AKT2

23.28

v-akt murine thymoma viral

Known

oncogene homolog 2, Diabetes, type II

7

TCF7L2

20.03

transcription factor 7 like 2,

Known

Diabetes, type 2, susceptibility to

8

IGF2BP2

17.77

insulin like growth factor 2

Known

mRNA binding protein 2, Diabetes,

noninsulin-dependent, susceptibility to

9

MAPK8IP1

14.52

mitogen-activated protein kinase 8

Known

interacting protein 1, Diabetes,

noninsulin-dependent

10

IRS2

12.78

insulin receptor substrate 2,

Known

Diabetes, noninsulin-dependent

11

NEUROD1

7.03

neurogenic differentiation 1,

Known

Diabetes, noninsulin-dependent

12

UBC

6.52

ubiquitin C

Novel

13

HNF1B

6

HNF1 homeobox B, Diabetes,

Known

noninsulin-dependent

14

EP300

4

E1A binding protein p300

Novel

15

CREBBP

4

CREB binding protein

Novel

16

ESR1

3.47

estrogen receptor 1

Novel

17

AKT1

3.02

v-akt murine thymoma

Novel

viral oncogene homolog 1

18

NRF1

3.02

NFKB repressing factor

Novel

19

PCBD1

3

pterin-4 alpha-carbinolamine dehydratase 1

Novel

20

SP1

3

Sp1 transcription factor

Novel

21

HDAC4

3

histone deacetylase 4

Novel

22

YWHAB

2.49

tyrosine 3-monooxygenase/tryptophan

Novel

5-monooxygenase activation protein beta

23

EGFR

2.47

epidermal growth factor receptor

Novel

24

GCK

2.45

glucokinase, Diabetes, noninsulin-dependent,

Known

late onset

25

ELAVL1

2.45

ELAV like RNA binding protein 1

Novel

26

APP

2.29

amyloid beta precursor protein

Novel

27

SUMO2

2.01

small ubiquitin-like modifier 2

Novel