Fig. 5

Visualization via conditioning plots of map computed for H-Ras WT. The map computed for the H-Ras WT is visualized via conditioning plots, which plot projections of the hall of fame on PC1 and PC2 conditional on projections on PC3 and PC4. Sixteeen plots are generated, considering combinations of all quartiles of PC3 with all quartiles of PC4. The 4D space in each subplot is discretized via hexagons, plotting for each hexagon only the projection of the lowest-energy individual in the hexagon. The blue-to-red color-coding scheme follows the low to blue energy range. Dots in yellow show PC1-PC2 projections of experimentally-known structures of H-Ras WT