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Table 4 Comparison of ensemble of low-cost on →off paths across H-Ras WT and variants

From: Computing energy landscape maps and structural excursions of proteins

Sequence m a x_n n_d i s t (Å) (μ,σ)Cost (REU) (μ,σ)Highest Energy (REU) (μ,σ)Nr. Edges
WT 1.45/10 (418.3, 106.) (–203.5, 25.1) (101.3, 16.1)
  1.45/7.5 (127.6, 7.90) (–277.3, 15.2) (64.2, 15.6)
G12S 1.45/10
  1.45/7.5 (143, 40.9) (–259, 92) (73, 22)
G12C 1.45/10
  1.45/7.5 (266.4, 18.2) (–139.3, 24.4) (60, 9.8)
G12D 1.45/10
  1.45/7.5 (140.4, 15.5) (–253.9, 15.9) (54.6, 8.6)
G12V 1.45/10
  1.45/7.5 (132.3, 13.5) (–236.3, 83.4) (64.6, 13.)
Q61L 1.45/10
  1.45/7.5 (161.3, 45.2) (–240.7, 21.8) (64.1, 9.2)
Y32CC118S 1.45/10
  1.45/7.5 (158.2, 18.9) (–257.5, 18.1) (63.9, 10.2)
R164AQ165V 1.45/10
  1.45/7.5 (159.7, 21.3) (–245.6, 23.8) (65.9, 7.1)