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Fig. 2 | BMC Genomics

Fig. 2

From: Purifying selection acts on coding and non-coding sequences of paralogous genes in Arabidopsis thaliana

Fig. 2

Paralogs with lower expression experience relaxed purifying selection. a Paralogs in the higher expression group (black bars) have more orthologs in A. lyrata than do their paralogs with lower expression (grey bars) (Fisher’s exact test, two-sided). White hatched bars show number of genes in A. thaliana that do not have an ortholog in A. lyrata. b The dN/dS ratio of A. thaliana and A. lyrata orthologs was compared between paralogs with similar expression (one paralog of each pair) and paralogs in groups with higher expression and lower expression. Letters indicate significant differences in sample distribution (P < 0.001, Kruskal-Wallis test with Dunn’s correction). c The gene expression profiles of paralogs with lower expression are less correlated with those of A. lyrata orthologs than are paralogs with higher or similar expression. Spearman correlation coefficients based on expression in A. thaliana and A. lyrata were calculated for paralogs with lower expression (ρ = 0.49, n = 109), higher expression (ρ = 0.54, n = 147), and all orthologs (ρ = 0.6, n = 15,134), indicated by black arrows. The correlation coefficient for differentially-expressed paralogs is different from that for paralogs with similar expression; grey bars show the distribution of ρ values based on 10,000 permutated sets of paralogs from pairs with similar expression (n = 245). Light grey bars indicate the distribution of 95 % of the resulting correlation coefficients, and dark grey bars indicate the 2.5 % distribution on either side. For details of the statistical analysis see main text

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