Fig. 4

Summary of functional gene ontological analyses significantly enriched based on early nutritional history in the liver. The biological significance of the 573 up-regulated mRNA probes and 351 down-regulated mRNA probes in the liver of trout based on nutritional history was ascertained by performing gene ontology (GO) analysis using the functional annotation cluster and chart tools from the DAVID (Database for Annotation, Visualization and Integrated Discovery) bioinformatics resource [137, 138]. The resulting data was used as input in the DAVID Enrichment Map plugin from the Bader Lab [139, 140] in the Cytoscape network visualization tool (version 2.8.3) [141–143]. The nodes (circles) represent individual GO terms and the lines represent the relationship between the genes assigned to respective GO terms. Blue and green lines represent up-regulated and down-regulated mRNA probes in the liver respectively