Table 4 Special types of DEGs during SUS progression in A. japonicus

Attachment/Pathogen recognition

 CLECT

−1.56

−1.79

−2.99

−3.27

−3.34

−3.77

 CLECT isoform 3

−1.69

−2.01

−2.21

−3.27

−3.23

−3.64

 CLEC19A

−1.71

−1.89

−2.12

−2.51

−2.68

−2.78

 GalNAc-specific lectin

−1.21

−1.52

−1.91

−5.37

−6.05

−6.58

 lactose-binding lectin l-2-like

^a

^a

−1.29

^a

−2.96

−3.24

 Fibrinogen-like protein A

−1.32

−1.25

−1.18

−2.74

−2.79

−2.18

 SRCR protein

3.47

3.62

3.91

5.32

5.27

5.68

 FNDC3A-like

7.49

7.51

6.39

5.09

5.08

4.91

 Annexin A13

1.56

1.64

1.27

2.21

1.69

1.33

 Mucin-2

6.21

5.49

7.66

8.78

8.38

8.64

 Integrin alpha-1

2.14

1.85

1.8

3.80

3.20

3.23

 Integrin alpha-9-like

4.6

4.02

5.08

5.45

4.77

4.65

 Integrin Alpha-Lv1

5.88

6.23

7.08

6.23

5.31

5.5

 Integrin beta-2

2.02

1.45

1.51

2.24

1.94

1.74

 Integrin beta-C subunit

13.24

12.8

11.31

5.31

5.31

5.24

 Integrin beta G subunit precursor

4.44

4.11

4.24

4.35

3.98

3.83

 Tenascin-R-like

−1.67

−2.28

−2.04

−1.18

−1.77

−1.89

Inflammation Reactions

 Complement C3

2.82

2.93

3.15

3.68

3.55

3.39

 Complement component 3-2

6.63

6.42

6.5

3.49

3.15

3.29

 Complement Bf

1.29

1.63

1.64

3.3

3.45

3.41

 Complement receptor type 2 isoform X1

2.71

3.43

2.87

3.42

4.25

3.51

 IgGFc-binding protein

3.21

3.31

2.51

4.99

4.85

4.2

 Collagen alpha-1 (XI) chain-like

5.12

5.27

5.11

5.99

5.91

5.81

 Collagen alpha-2

7.11

6.34

6.03

5.93

5.06

5.13

 Collagen alpha-5

4.51

3.62

3.31

5.02

4.52

4.06

 MyD88

1.36

1.38

1.54

1.60

1.64

1.75

 TRAF 1

2.29

2.63

2.69

4.02

4.1

4.42

 TRAF5-like

5.46

7.65

5.94

2.44

2.93

2.57

 IRAK4-like

3.65

3.57

3.91

3.7

3.09

2.86

 NF-kB transcription factor Rel

3.25

3.78

3.48

3.64

4.11

3.91

 NF-kB p105 subunit

3.45

3.54

3.82

4.17

4.22

4.4

 MAPKKK

2.25

2.25

2.17

2.38

2.81

2.61

 Serine/threonine-protein kinase TBK1-like

4.82

5.07

4.79

5.46

5.31

5.12

 Stress-activated protein kinase JNK-like

4.24

4.21

4.33

3.89

3.63

4.02

 TGF beta-activated kinase

2.89

2.98

2.96

4.35

4.21

4.53

 TOLLIP

3.41

3.79

3.56

3.43

4.25

3.91

 Zonadhesin-like

6.67

5.5

6.97

11.89

11.85

11.38

 IFI27-like protein 2

−2.64

−2.47

−2.38

−3.02

−2.93

−3.17

 Apolipoprotein B-100-like

3.47

3.83

4.22

2.93

3.18

3.56

 Macrophage mannose receptor 1-like

3.01

3.25

3.18

4.3

4.63

4.72

 Matrix metalloproteinase-9

5.72

4.84

5.42

8.41

7.71

8.15

 Matrix metalloproteinase-24

3.91

3.71

4.01

2.41

1.41

1.57

 Matrix metalloproteinase 24 preproprotein-like

4.52

3.43

3.59

3.91

3.71

4.01

 Prostaglandin E synthase 2-like

1.26

1.42

1.23

1.51

1.77

1.85

 Suppressor of cytokine signaling 2-like

5.33

4.89

5.18

4.95

4.45

4.81

 Tumor protein p53-inducible protein 11-like

2.34

2.59

2.26

4.23

4.79

4.42

 NFIL3

2.07

2.96

2.38

3.21

2.38

1.41

 TMPRSS 5-like

10.34

10.37

10.79

10.39

10.41

10.83

 LENG8 homolog

4.28

4.44

3.99

5.37

5.48

5.04

 IGDCC4-like

3.76

3.08

3.15

1.87

1.95

1.88

 LIG-3 isoform 2

2.22

2.51

2.41

3.45

3.94

3.63

 Variable lymphocyte receptor

2.02

2.27

2.28

9.74

11.04

11.26

 Thrombospondin-2

4.31

4.22

3.88

3.13

3.01

2.72

 Thrombospondin-3

5.28

5.08

5.31

4.77

4.49

4.86

 Major yolk protein

−2.63

−2.51

−2.13

−3.07

−3.03

−3.45

Oxidative Stress Response

 HSP 70

3.84

5.24

5.09

3.76

5.17

5.06

 HSP 26

3.59

5.84

5.58

2.63

4.55

4.54

 HSP 110

2.08

1.63

1.73

3.33

2.96

3.26

 HSP 90

7.13

7.42

7.83

2.31

1.59

1.75

 Dual oxidase 1

4.36

4.27

4.41

4.82

4.54

4.65

 GPX1-like

2.09

1.92

1.62

2.72

2.50

2.65

 Thioredoxin

2.33

2.19

2.32

2.91

2.7

3.38

Apoptosis/Autophagy/Lysosome/Phagosome

 Apoptosis regulator BAX-like

2.02

2.27

2.45

7.72

7.52

8.36

 Apoptosis-inducing factor 2-like

2.08

2.14

1.99

2.21

2.48

2.01

 Calpain-5

2.65

2.64

2.08

4.77

4.79

4.20

 Calpain-7

1.96

1.94

1.99

3.06

3.12

3.08

 Caspase-6-like

3.82

4.12

4.36

2.12

3.31

2.44

 Cyclophilin B

1.97

1.96

1.91

1.90

2.03

2.30

 Cytochrome c-like

−1.14

−1.32

−1.22

−1.65

−1.84

−1.75

 Cytochrome c oxidase subunit 7C

−2.06

−1.95

−1.95

−2.57

−2.65

−2.76

 BFAR -like

2.57

3.19

2.73

8.03

8.15

7.95

 Bcl-2 protein

5.29

4.83

4.67

4.08

3.65

3.43

 Bcl-2-like protein 1-like

2.25

2.58

2.32

4.04

4.34

4.14

 BIRC2

3.28

2.9

3.01

3.8

3.52

3.42

 BIRC 6-like

3.18

3.17

2.96

5.06

5.11

4.89

 PDCD6IP -like

2.17

2.17

2.22

3.61

3.77

3.69

 PDCD10 -like

3.79

3.47

3.54

4.41

4.29

4.32

 DRAM 2-like

2.38

2.54

2.95

3.93

4.24

4.19

 PDRG 1

−2.83

−2.83

−1.83

−3.81

−3.51

−3.13

 Exportin-1-like

1.59

1.52

1.59

11.77

10.38

11.82

 Exportin-T

1.37

1.49

1.61

1.64

1.42

1.59

 Cathepsin D

7.13

7.47

7.44

6.13

7.16

8.09

 Cathepsin L

1.72

1.83

1.79

3.18

3.84

4.71

 Cathepsin B-like protease

3.08

3.19

3.25

3.23

3.37

3.57

 Lysozyme-like

−1.51

^a

−1.69

−3.38

^a

−3.67

 Autophagy-related protein 2 homolog B

6.46

6.31

5.79

3.82

4.29

3.75

 Lysosome membrane protein 2-like

4.27

4.72

3.11

4.39

4.03

3.55

 Lysosomal alpha-mannosidase-like

2.34

2.56

2.51

9.49

10.11

10.05

 Lysosomal-trafficking regulator-like

1.92

1.51

1.43

4.85

4.68

4.7

 ADP-ribosylation factor-like 1

1.72

1.42

1.58

6.12

6.09

6.43

 ADP-ribosylation factor-like 3

2.32

1.51

2.68

4.25

4.61

4.52

 Beta-galactosidase-like

1.66

1.42

1.78

4.11

4.01

3.61