Table 2 Genes investigated for NAFLD associated changes in methylation
Bile acids (gene cluster 1) | Drug metabolism (gene cluster 2) | ||||||
|---|---|---|---|---|---|---|---|
Transport | Synthesis and metabolism | Signaling and gene regulation | Conjugation | Phase I metabolism | Phase II metabolism | Transporters | Regulation of expression |
ABCB1 | CYP27A1 | FGF19 | BAAT | CYP1A1 | UGT1A1 | SLC22A1 | HNF1α |
ABCB11 | CYP39A1 | FGFR4 | SLC27A5 (BACS) | CYP1A2 | UGT1A4 | SLC22A2 | NR2A1 (HNF4α) |
ABCB4 | CYP3A4 | NR1H4 (FXR) | CYP2A6 | UGT2B7 | SLC22A6 | AhR | |
ABCC2 | CYP7A1 | HNF1α | CYP2B6 | SULT1A1 | SLC22A7 | NR1I2 (PXR) | |
ABCC3 | CYP7B1 | NR2A1 (HNF4α) | CYP2C8 | GSTM1 | SLC22A8 | NR1I3 (CAR) | |
ABCC4 | CYP8B1 | NR0B2 | CYP2C9 | GSTP1 | SLC47A1 | NR3C1 (GR) | |
ABCG1 | EPHX | NR1I2 (PXR) | CYP2C19 | GSTT1 | SLCO1A2 | PPARγ | |
ABCG5 | HSD3B7 | NR1I3 (CAR) | CYP2D6 | SLCO1B1 | NR2B1 (RXRα) | ||
ABCG8 | SCP2 | NR5A2 (LRH-1) | CYP2E1 | SLCO1B3 | NR3A1 (ERɑ) | ||
ATP8B1 | AKR1D1 | NR2B1 (RXRα) | CYP3A4 | SLCO2B1 | |||
SLC10A1 | SULT2A1 | KL (Klotho β) | TPMT | ABCB1 | |||
SLC10A2 | UGT2B11 | ABCC2 | |||||
SLCO1A2 | ABCG2 | ||||||
SLCO1B1 | |||||||
SLCO1B3 | |||||||
SLCO2B1 | |||||||
SLC51A (OSTα) | |||||||
SLC52A (OSTβ) | |||||||