Pearson correlation analysesc | |||||||||
---|---|---|---|---|---|---|---|---|---|
CpG-sites | Robust linear regression (n = 50)b | SS & NASH (n = 20) | Controls (n = 30) | ||||||
Gene | Total | sign.a | p (binomial) | Coef. | p | Coef. | p | Coef. | p |
Hypermethylated targets | |||||||||
ABCC2 | 5 | 3 | 1.16E-03 | - | ns | - | ns | - | ns |
CYP1A1 | 17 | 6 | 1.20E-04 | -0.42 | 3.83E-02 c | - | ns | - | ns |
CYP1A2 | 3 | 2 | 7.25E-03 | -0.42 | 3.47E-03 | - | ns | - | ns |
CYP2B6 | 8 | 2 | ns | 0.41 | 1.00E-03 | - | ns | 0.43 | 1.64E-02 |
CYP2C19 | 6 | 3 | 2.23E-03 | -0.44 | 4.50E-05 | - | ns | -0.44 | 1.43E-02 |
CYP2C9 | 2 | 2 | 2.50E-03 | - | ns | - | ns | - | ns |
CYP2D6 | 3 | 2 | 7.25E-03 | - | ns | - | ns | - | ns |
CYP2E1 | 7 | 6 | 1.05E-07 | - | ns | - | ns | - | ns |
HNF1A | 8 | 8 | 3.91E-11 | - | ns | - | ns | - | ns |
NR2A1 | 18 | 15 | 2.16E-17 | - | ns | - | ns | - | ns |
NAT2 | 2 | 1 | ns | -0.26 | 1.31E-02 | - | ns | - | ns |
NR1I3 | 4 | 3 | 4.81E-04 | - | ns | - | ns | - | ns |
SLC22A1 | 3 | 3 | 1.25E-04 | - | ns | - | ns | - | ns |
SLC22A7 | 2 | 2 | 2.50E-03 | - | ns | - | ns | - | ns |
SLC47A1 | 15 | 6 | 5.28E-05 | -0.34 | 8.43E-05 | - | ns | -0.41 | 2.31E-02 |
SLCO2B1 | 9 | 5 | 3.32E-05 | -0.38 | 1.41E-03 | - | ns | - | ns |
SULT1A1 | 7 | 3 | 3.76E-03 | -0.42 | 1.31E-04 | - | ns | -0.54 | 2.15E-03 |
UGT1A4 | 5 | 2 | 2.26E-02 | -0.63 | 4.52E-02 | - | ns | - | ns |
UGT2B7 | 2 | 1 | ns | -0.53 | 4.01E-03 | - | ns | -0.43 | 1.76E-02 |
Hypomethylated targets | |||||||||
CYP3A4 | 3 | 2 | 7.25E-03 | - | ns | - | ns | - | ns |
GSTP1 | 10 | 1 | ns | -0.36 | 2.43E-02 | - | ns | - | ns |
NR1I2 | 5 | 2 | 2.26E-02 | - | ns | - | ns | - | ns |
NR2B1 | 9 | 1 | ns | - | ns | - | ns | 0.42 | 2.09E-02 |
NR3A1 | 47 | 20 | 2.50E-14 | - | ns | - | ns | - | ns |
SLC22A2 | 10 | 3 | 1.15E-02 | - | ns | - | ns | - | ns |
SLCO2B1 | 9 | 1 | ns | 0.26 | 7.07E-03 | - | ns | 0.47 | 8.22E-03 |
UGT1A1 | 2 | 1 | ns | - | ns | - | ns | -0.36 | 4.90E-02 |
UGT1A4 | 5 | 2 | 2.26E-02 | - | ns | - | ns | - | ns |