Fig. 4
From: Self-regulation of functional pathways by motifs inside the disordered tails of beta-catenin
Correlation between functional variations and point mutations at different regions. By using FATHMM, all the mutations were assigned into one of the four groups based on two independent criteria: Damaging (or Tolerant) and Cancer-promoting (or non-Cancer-promoting). a Distribution of point mutations along the amino acid sequence of beta-Catenin in four groups (from top to bottom): Damaging and Cancer-promoting; Damaging and non-Cancer-promoting; Tolerant and Cancer-promoting; and Tolerant and non-Cancer-promoting. Y-axis shows the frequency of mutations at each sequential site. b Quartile distribution plot on the variation of structural flexibility caused by point mutation in afore-mentioned four groups of mutations (x-axis) for three different regions of beta-Catenin (top: the N-ter tail; middle: the C-ter tail; and bottom: the ARM domain). The structural flexibility was characterized using disorder score predicted by PONDR-FIT. The variation of structural flexibility at a specific site was calculated as the ratio of the change of disorder score at that site caused by the mutation to the disorder score at the same site of the wild-type sequence