Fig. 4

Recessively inherited arthrogryposis multiplex congenital (AMC) in Red dairy cattle maps to chromosome 19. a Familial relationships between the three AMC affected calves (filled symbols). Males are represented by squares, females by circles. Half-filled symbols represent healthy obligate heterozygous carriers and open symbols represent healthy relatives with an unknown genotype. DNA samples were available only from 11 animals of which the CHRNB1 genotypes are shown below the symbol. The common male ancestor (The sire Peterslundborn in 1997) and possible founder animal is marked by a red arrow. b Parametric linkage analysis for a recessive trait in the family and homozygosity analysis across the three AMC cases yielded several linked genome segments (blue) and a single homozygous genome segment (red). Only one region on chromosomes 19 showed both linkage and homozygosity and were considered as the critical interval (the position of the AMC associated CHRNB1 gene is indicated)