Fig. 6
From: The genome-wide role of HSF-1 in the regulation of gene expression in Caenorhabditis elegans
Age-regulated genes controlled by HSF-1. a The Venn diagram shows the overlap among genes that are differentially expressed during aging and regulated by HSF-1 during HS. The Venn diagram was made using genes previously found to be regulated during aging by Budovskaya et al. compared to genes we found to be regulated by HSF-1 during HS. b Cellular processes affected by aging and HSF-1 during HS. Genes shared between the aging dataset and HSF-1-regulated HS-dependent dataset from (a) were analyzed with DAVID and the Gene Ontology terms are listed in order of decreasing enrichment. c Network analysis of the genes regulated by aging and HSF-1 during HS. Network analysis was done with MiMI using the Cytoscape platform and the transcripts shared between data-sets (see Additional file 6: Table S5). The color of each transcript corresponds to the degree of HSF-1 regulation. Genes that are not colored were not affected by HSF-1 our dataset, but are neighbors shared by at least two genes that were affected in our dataset. d The Venn diagram shows the overlap among genes that are differentially expressed during aging and regulated by HSF-1 independently of HS. The Venn diagram was made using genes previously found to be regulated during aging by Budovskaya et al. compared to genes we found to be regulated by HSF-1 independently of HS. e Cellular processes affected by aging and HSF-1 independently of HS. Genes shared between the aging dataset and HSF-1-regulated HS-independent dataset from (c) were analyzed with DAVID and the Gene Ontology terms are listed in order of decreasing enrichment. f Network analysis of the genes regulated by aging and HSF-1 independently of HS. Network analysis was done with MiMI using the Cytoscape platform and the transcripts shared between data-sets (see Additional file 7: Table S6). The color of each transcript corresponds to the degree of HSF-1 regulation. Genes that are not colored were not affected by HSF-1 in our dataset, but are neighbors shared by at least two genes that were affected in our dataset