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Table 4 Top 15 genes normally downregulated by HSF-1 independently of HS

From: The genome-wide role of HSF-1 in the regulation of gene expression in Caenorhabditis elegans

 

Transcript ID

Gene Name

Fold Change (log2) control vs. hsf-1(-);-HS

Description (WormBase)

1

T22F3.11

T22F3.11

−5.85

T22F3.11 encodes an ortholog of human solute carrier family 17

2

T26F2.3

eol-1

−5.38

eol-1 is required in the URX sensory neurons for inhibition of olfactory learning

3

B0348.2

B0348.2

−5.32

B0348.2 encodes an ortholog of human lipopolysaccharide-induced TNF factor

4

Y47H10A.5

Y47H10A.5

−5.17

Unknown function

5

D2023.7

col-158

−5.17

col-158 is predicted to be a structural constituent of the cuticle

6

C08E3.6

fbxa-163

−4.95

fbxa-163 encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions

7

F07E5.9

F07E5.9

−4.90

Unknown function

8

Y46C8AL.2

clec-174

−4.89

clec-174 is predicted to have carbohydrate binding activity

9

T07H8.5

srg-31

−4.84

srg-31 is involved in embryo development and is predicted to have transmembrane signaling receptor activity

10

ZK666.6

clec-60

−4.81

clec-60 appears to play a role in the innate immune response to some bacterial pathogens

11

B0507.8

B0507.8

−4.64

B0507.8 encodes an ortholog of human cingulin-like 1

12

ZK355.8

ZK355.8

−4.60

Unknown function

13

H16D19.1

clec-13

−4.50

clec-13 is predicted to have carbohydrate binding activity

14

T08E11.1

T08E11.1

−4.37

T08E11.1 encodes a protein containing an F-box motif predicted to mediate protein-protein interactions

15

F22G12.1

F22G12.1

−4.35

F22G12.1 encodes an ortholog of human GRB10 interacting GYF protein 2

  1. The transcript ID, gene name, and fold change in gene expression in the comparison of the control vs hsf-1(-);-HS are listed for the top 15 genes normally downregulated by HSF-1 independently of HS. Gene descriptions, as provided from WormBase, are also listed. A complete list of the significantly altered transcripts is given (see Additional file 2: Table S1)