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Fig. 2 | BMC Genomics

Fig. 2

From: Genomic and expression analyses of Tursiops truncatus T cell receptor gamma (TRG) and alpha/delta (TRA/TRD) loci reveal a similar basic public γδ repertoire in dolphin and human

Fig. 2

Schematic representation of the genomic organization of the bottlenose dolphin (Tursiops truncatus) TRA/TRD locus as deduced from the genome assembly Ttru_1.4. a The diagram shows the position of the TRDV, TRDD, TRDJ and TRDC genes and of the TRAV, TRAJ and TRAC genes according to the IMGT® nomenclature. The retrieval of the relevant contigs from the GenBank (JH484271.1 and JH481615.1) and Ensembl databases (S_742; S_97; S_89; S_123 and S_112178), has allowed the identification, starting from the 5′ end of the locus, of 16 TRAV (including 5 pseudogenes), 5 TRDV (including 1 pseudogene), 2 TRDD, 4 TRDJ (including one ORF and 1 pseudogene), 1 TRDC, 59 TRAJ and 1 TRAC genes, located in a genomic region spanning approximatively 450 Kb (Additional file 5). Boxes representing genes are not to scale. Exons are not shown. Arrow head indicates the transcriptional orientation of the TRDV4 gene. The arrows above the line of the TRAJ genes indicate the 70 kb region that has been magnified in the lower part of the figure. b IMGT Protein display for the dolphin TRAV and TRDV functional genes. The description of the strands and loops is according to the IMGT unique numbering for V-REGION [25]. 1st-CYS C23, CONSERVED-TRP W41, hydrophobic L89 and 2nd-CYS C104 are colored (IMGT color menu) and in bold

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BMC Genomics

ISSN: 1471-2164

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