Deciphering transcriptome profiles of peripheral blood mononuclear cells in response to PRRSV vaccination in pigs

BMC Genomics

Table 2 Significantly enriched gene sets (pathway) obtained from gene set enrichment analysis. Top most gene sets enriched in PBMCs of PRRSV vaccinated pigs compared to unvaccinated control pigs exported from GSEA desktop application

Gene sets	6hpv_vacc vs. 6hpv_unvacc		24hpv_vacc vs. 24hpv_unvacc
Gene sets	NES	FDR	NES	FDR
Regulation of actin cytoskeleton	2.51	0.001	2.75	0.001
Chemokine signaling pathway	2.48	0.001	2.56	0.001
JAK-STAT signaling pathway	2.39	0.001	2.55	0.001
Integrin cell surface interactions	2.46	0.001	2.5	0.001
Cell adhesion molecules	2.31	0.001	2.38	0.001
Integrin signaling pathway	2.28	0.001	2.37	0.001
Cell surface interactions at the vascular wall	2.27	0.001	2.33	0.001
Signal transduction by L1	2.24	0.007	2.27	0.007
Cytokine cytokine receptor interaction	2.20	0.008	2.25	0.007
Apoptosis by serum deprivation up	2.17	0.008	2.23	0.007
Immortalized by HPV31 DN	2.16	0.008	2.23	0.008
Signaling by FGFR1 mutants	2.14	0.011	2.21	0.010
TNF signaling up	2.12	0.014	2.19	0.013
ECM receptor interaction	2.10	0.025	2.13	0.021
TRAF trafficking pathway	2.08	0.013	2.12	0.011
Leukocyte transendothelial migration	2.04	0.008	2.14	0.007

ISSN: 1471-2164