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Table 3 Gene ontology terms enriched by the DEGs. Top 30 GO terms of biological process involved with the vaccine induced DEGs retrieved from InnateDB pathway analysis tool. The significance of over-representation was defined by multiple test corrected p-value of <0.05

From: Deciphering transcriptome profiles of peripheral blood mononuclear cells in response to PRRSV vaccination in pigs

Time points GO ID GO term Nr. of genes involved Adjusted p-value
6 hpv GO:0045087 Innate immune response 18 0.01
GO:0042493 Response to drug 9 0.05
GO:0034097 Response to cytokine 5 0.02
GO:0016567 Protein ubiquitination 8 0.01
GO:0043687 Post-translational protein modification 7 0.01
GO:0044281 Small molecules metabolic process 30 0.01
GO:0015031 Protein transport 10 0.03
GO:0006355 Regulation of transcription, DNA-template 28 0.03
GO:0007186 G-protein coupled receptor signaling pathway 15 0.03
GO:0044267 Cellular protein metabolic process 14 0.03
24 hpv GO:0045087 Innate immune response 90 0.01
GO:0007165 Signal transduction 82 0.01
GO:0008284 Positive regulation of cell proliferation 45 0.02
GO:0016032 Viral process 37 0.01
GO:0051607 Defense response to virus 14 0.02
GO:0043406 Positive regulation of MAPK kinase activity 9 0.05
GO:0006874 Cellular calcium ion homeostasis 11 0.08
GO:0007265 Ras protein signal transduction 8 0.02
GO:0030217 T cell differentiation 5 0.05
GO:0035666 TRIF-dependent toll-like receptor signaling pathway 8 0.05
72 hpv GO:0043408 Regulation of MAPK cascade 7 0.04
GO:0007067 Mitotic nuclear division 6 0.04
GO:0019221 Cytokine-mediated signaling pathway 5 0.03
GO:0006935 Chemotaxis 4 0.04
GO:0007155 Cell adhesion 7 0.05
GO:0051726 Regulation of cell cycle 9 0.05
GO:0055085 Transmembrane transport 14 0.03
GO:0010467 Gene expression 6 0.05
GO:0006915 Apoptotic process 8 0.04
GO:0009615 Response to virus 5 0.14