Table 3 Gene ontology terms enriched by the DEGs. Top 30 GO terms of biological process involved with the vaccine induced DEGs retrieved from InnateDB pathway analysis tool. The significance of over-representation was defined by multiple test corrected p-value of <0.05
Time points | GO ID | GO term | Nr. of genes involved | Adjusted p-value |
|---|---|---|---|---|
6 hpv | GO:0045087 | Innate immune response | 18 | 0.01 |
GO:0042493 | Response to drug | 9 | 0.05 | |
GO:0034097 | Response to cytokine | 5 | 0.02 | |
GO:0016567 | Protein ubiquitination | 8 | 0.01 | |
GO:0043687 | Post-translational protein modification | 7 | 0.01 | |
GO:0044281 | Small molecules metabolic process | 30 | 0.01 | |
GO:0015031 | Protein transport | 10 | 0.03 | |
GO:0006355 | Regulation of transcription, DNA-template | 28 | 0.03 | |
GO:0007186 | G-protein coupled receptor signaling pathway | 15 | 0.03 | |
GO:0044267 | Cellular protein metabolic process | 14 | 0.03 | |
24 hpv | GO:0045087 | Innate immune response | 90 | 0.01 |
GO:0007165 | Signal transduction | 82 | 0.01 | |
GO:0008284 | Positive regulation of cell proliferation | 45 | 0.02 | |
GO:0016032 | Viral process | 37 | 0.01 | |
GO:0051607 | Defense response to virus | 14 | 0.02 | |
GO:0043406 | Positive regulation of MAPK kinase activity | 9 | 0.05 | |
GO:0006874 | Cellular calcium ion homeostasis | 11 | 0.08 | |
GO:0007265 | Ras protein signal transduction | 8 | 0.02 | |
GO:0030217 | T cell differentiation | 5 | 0.05 | |
GO:0035666 | TRIF-dependent toll-like receptor signaling pathway | 8 | 0.05 | |
72 hpv | GO:0043408 | Regulation of MAPK cascade | 7 | 0.04 |
GO:0007067 | Mitotic nuclear division | 6 | 0.04 | |
GO:0019221 | Cytokine-mediated signaling pathway | 5 | 0.03 | |
GO:0006935 | Chemotaxis | 4 | 0.04 | |
GO:0007155 | Cell adhesion | 7 | 0.05 | |
GO:0051726 | Regulation of cell cycle | 9 | 0.05 | |
GO:0055085 | Transmembrane transport | 14 | 0.03 | |
GO:0010467 | Gene expression | 6 | 0.05 | |
GO:0006915 | Apoptotic process | 8 | 0.04 | |
GO:0009615 | Response to virus | 5 | 0.14 |