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Table 1 The top significantly enriched GO BP, MF and MetaCore “Process Networks” annotationsa

From: Quantitative analyses of the hepatic proteome of methylmercury-exposed Atlantic cod (Gadus morhua) suggest oxidative stress-mediated effects on cellular energy metabolism

#

A) GO processes

In data

FDR

1

Small molecule metabolic process

56

2.049E-11

2

Response to inorganic substance

29

4.840E-10

3

Macromolecular complex remodeling

10

4.840E-10

4

Plasma lipoprotein particle remodeling

10

4.840E-10

5

Protein-lipid complex remodeling

10

4.840E-10

6

Cholesterol efflux

10

1.124E-09

7

Glycerolipid catabolic process

11

1.124E-09

8

Single-organism metabolic process

76

1.931E-09

9

Metabolic process

121

1.931E-09

10

Plasma lipoprotein particle organization

10

2.287E-09

#

B) GO Molecular functions

In Data

FDR

1

Oxidoreductase activity

19

7.654E-04

2

Catalytic activity

63

7.654E-04

3

Phosphatidylcholine-sterol

O-Acyltransferase activator activity

3

7.654E-04

4

Small molecule binding

37

7.654E-04

5

Cholesterol transporter activity

4

7.654E-04

6

Sterol transporter activity

4

7.654E-04

7

Antioxidant activity

6

7.654E-04

8

Poly(A) RNA binding

21

1.899E-03

9

Anion binding

36

2.555E-03

10

Nucleotide binding

32

2.621E-03

#

C) Process Networks

In Data

FDR

1

Translation_Translation initiation

9

1.001E-02

2

Response to hypoxia and oxidative stress

8

1.999E-02

3

Cytoskeleton_Actin filaments

8

2.223E-02

4

Cell adhesion_Cell junctions

7

4.893E-02

  1. aOnly the top 10 enriched GO BP (A) and MF (B) are shown here, and the full list of top 50 significantly enriched (FDR < 0.05) GO BP and MF terms and the associated proteins are presented in Additional file 4: Table S3