TY - JOUR AU - Woo, Hyung Jun AU - Yu, Chenggang AU - Kumar, Kamal AU - Gold, Bert AU - Reifman, Jaques PY - 2016 DA - 2016/08/30 TI - Genotype distribution-based inference of collective effects in genome-wide association studies: insights to age-related macular degeneration disease mechanism JO - BMC Genomics SP - 695 VL - 17 IS - 1 AB - Genome-wide association studies provide important insights to the genetic component of disease risks. However, an existing challenge is how to incorporate collective effects of interactions beyond the level of independent single nucleotide polymorphism (SNP) tests. While methods considering each SNP pair separately have provided insights, a large portion of expected heritability may reside in higher-order interaction effects. SN - 1471-2164 UR - https://doi.org/10.1186/s12864-016-2871-3 DO - 10.1186/s12864-016-2871-3 ID - Woo2016 ER -