Table 1 Pathways highly associated with AMD in collective inference
Rank | Pathway | No. of SNPs | AUC a | p-value b |
|---|---|---|---|---|
1 | Regulation of complement cascade | 448 | 0.688 (0.018) | 9×10−16 |
2 | Complement cascade | 869 | 0.684 (0.018) | 2×10−15 |
3 | Innate immune system | 14, 406 | 0.627 (0.019) | 2×10−10 |
4 | Immune system | 25, 770 | 0.601 (0.020) | 3×10−8 |
5 | Activation of C3 and C5 | 147 | 0.587 (0.020) | 5×10−7 |
6 | Initial triggering of complement | 522 | 0.584 (0.020) | 1×10−6 |
7 | Alternative complement activation | 118 | 0.581 (0.020) | 2×10−6 |
8 | Regulation of TP53 activity through methylation | 322 | 0.581 (0.020) | 2×10−6 |
9 | Synthesis of phosphatidic acid | 559 | 0.575 (0.020) | 7×10−6 |
10 | Glycerophospholipid biosynthesis | 1, 969 | 0.571 (0.020) | 1×10−5 |
11 | Protein folding | 1, 777 | 0.570 (0.020) | 2×10−5 |
12 | Chaperonin-mediated protein folding | 1, 661 | 0.570 (0.020) | 2×10−5 |
13 | Degradation of extracellular matrix | 2, 324 | 0.570 (0.020) | 2×10−5 |