Supplements of vitamins B9 and B12 affect hepatic and mammary gland gene expression profiles in lactating dairy cows

Ouattara, Bazoumana; Bissonnette, Nathalie; Duplessis, Melissa; Girard, Christiane L.

doi:10.1186/s12864-016-2872-2

Table 2 Identification of the major biological processes of the genes differentially expressed in hepatic tissue^a

From: Supplements of vitamins B9 and B12 affect hepatic and mammary gland gene expression profiles in lactating dairy cows

Biological process		Genes
Level 1	Level 2/3	Symbol	Fold Change
apoptotic process	negative regulation of apoptotic process	LOXL4	1.6
biological adhesion	cell adhesion	MYOM1 SPP1 MEP1B LOXL4	−2.5 0.9 1.3 1.6
biological regulation	regulation of biological process	DLK1 SFRP1 ID1 LOXL4	−2.5 −1.8 1.1 1.6
	regulation of molecular function	MYOM1 CDK5R1 PPP1R3B MEP1B LOC515676	−2.5 0.8 1.1 1.3 1.9
cellular component organization or biogenesis	cellular component organization	SPP1	0.9
cellular process	cell communication	DLK1 MYOM1 SFRP1 MEP1B LOXL4	−2.5 −2.5 −1.8 1.3 1.6
cellular process	cell cycle	CDK5R1 SESN2	0.8 0.9
developmental process	anatomical structure morphogenesis	SPP1	0.9
	death	LOXL4	1.6
	ectoderm development	DLK1 MEP1B	−2.5 1.3
	mesoderm development	MYOM1 MEP1B	−2.5 1.3
	system development	DLK1 MYOM1 SFRP1 MEP1B IGLL1	−2.5 −2.5 −1.8 1.3 2.1
immune system process	antigen processing and presentation	LOC100126815 MGC126945	−2.4 −1.8
	immune response	LOC100126815 MGC126945 HP IGLL1	−2.4 −1.8 −1.6 2.1
	macrophage activation	LOXL4	1.6
localization	transport	DLK1 LOC509034 SAA3 CACNA2D1 MEP1B LOXL4	−2.5 −1.5 −1.1 −1.0 1.3 1.6
metabolic process	catabolic process	HERC6	1.8
	carbohydrate metabolic process	PPP1R3B	1.1
	cellular amino acid metabolic process	PYCR1	1.5
	nucleobase-containing compound metabolic process	DLK1 ID1	−2.5 1.1
	protein metabolic process	MYOM1 HP CDK5R1 MEP1B LOXL4 FUT5 HERC6 LOC515676 ISG15	−2.5 −1.6 0.8 1.3 1.6 1.6 1.8 1.9 2.5
multicellular organismal process	single-multicellular organism process	MYOM1 SFRP1 HP MEP1B LOXL4	−2.5 −1.8 −1.6 1.3 1.6
reproduction	gamete generation	HP	−1.6
response to stimulus	cellular defense response	LOC100126815 MGC126945 LOXL4	−2.4 −1.8 1.6
	immune response	LOC100126815 MGC126945 HP IGLL1	−2.4 −1.8 −1.6 2.1
	response to external stimulus	HP MEP1B	−1.6 1.3
	response to stress	HP	−1.6
Not found		C20H5orf49 LOC789904 SLC22A9 CFH SLC26A10 SAA2 M-SAA3 LOC100847494 LOC100335975 LOC617654	−1.9 −1.8 −1.7 −1.5 −1.4 −1.2 −1.1 −0.9 1.4 4.2
Unassigned		C4H7orf57 MT1E MT1A THRSP KIAA1324 NGEF GSTA5 ACMSD NHEDC1 NEFH G0S2 LOC524810 IFI27 IFI6	−4.4 −3.4 −3.3 −1.7 −1.6 −1.4 −1.3 −1.2 −1.1 −1.1 1.9 2.6 3.3 3.7

All genes modulated in the liver by the vitamins treatment, including those that were not found or classified by the Panther system are listed. The fold change observed by microarray analysis varies from −4.4 to 4.2 and only significantly (FDR ≤ 0.05) expressed genes (compared to control) are shown
^aIdentification of the major biological processes of the genes differentially expressed in hepatic tissue of cows receiving vitamin supplements (vitamin B9 alone: B9, vitamin B12 alone: B12 or both vitamins: B9 + B12) as compared to no vitamins treatment (Control)

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ISSN: 1471-2164

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