Fig. 8

Gene network. Gene network showing the interaction of the orthologous genes pomc-a and pomc-b obtained by GeneMANIA. Genes having physiological interactions either with pomc-a or pomc-b were used to create GeneMania network. Input genes are indicated with stripes and are either of black, red or blue color. Intermediate genes added by the tool are illustrated in grey circles. Colored genes denote functions associated by the tools: blue = “G-protein coupled receptor signaling pathway”; red = “G-protein coupled peptide receptor activity”. Edge colors indicate the type of interaction: shared protein domains (green), co-expressed genes (violet) and physical interactions (pink) are shown